The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer's Disease

被引：53

作者：

Sahab-Negah, Sajad ^{[1
,2
,3
]}

Hajali, Vahid ^{[1
,2
]}

Moradi, Hamid Reza ^{[4
]}

Gorji, Ali ^{[1
,2
,3
,5
,6
,7
]}

机构：

[1] Mashhad Univ Med Sci, Neurosci Res Ctr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Fac Med, Dept Neurosci, Mashhad, Iran

[3] Khatam Alanbia Hosp, Shefa Neurosci Res Ctr, Tehran, Iran

[4] Shiraz Univ, Fac Vet Med,, Basic Sci Dept, Histol & Embryol Grp, Shiraz, Iran

[5] Westfal Wilhelms Univ Munster, Dept Neurol, Munster, Germany

[6] Westfal Wilhelms Univ Munster, Dept Neurosurg, Munster, Germany

[7] Westfal Wilhelms Univ Munster, Epilepsy Res Ctr, Domagkstr 11, Munster, Germany

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2020年 / 40卷 / 03期

基金：

美国国家科学基金会;

关键词：

Neurodegeneration; Dementia; Hormone; Neurogenesis; Cell therapy; Brain; ADULT HIPPOCAMPAL NEUROGENESIS; ESTROGEN-RECEPTOR-ALPHA; NEUROTROPHIC FACTOR BDNF; OBJECT MEMORY CONSOLIDATION; GONADAL HORMONE MODULATION; GROWTH FACTOR INTERACTIONS; CENTRAL-NERVOUS-SYSTEM; FACTOR MESSENGER-RNA; DENTATE GYRUS; CELL-PROLIFERATION;

D O I：

10.1007/s10571-019-00733-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD) is described as cognitive and memory impairments with a sex-related epidemiological profile, affecting two times more women than men. There is emerging evidence that alternations in the hippocampal neurogenesis occur at the early stage of AD. Therapies that may effectively slow, stop, or regenerate the dying neurons in AD are being extensively investigated in the last few decades, but none has yet been found to be effective. The regulation of endogenous neurogenesis is one of the main therapeutic targets for AD. Mounting evidence indicates that the neurosteroid estradiol (17 beta-estradiol) plays a supporting role in neurogenesis, neuronal activity, and synaptic plasticity of AD. This effect may provide preventive and/or therapeutic approaches for AD. In this article, we discuss the molecular mechanism of potential estradiol modulatory action on endogenous neurogenesis, synaptic plasticity, and cognitive function in AD.

引用

页码：283 / 299

页数：17