Synthesis, crystal structure, spectral and biological studies of CuII-MII(M = Zn and Pb) heterodinuclear complexes of new phenol-based macrocyclic ligands

Eight new heterodinuclear Cu(II)-M(II) (M = Pb and Zn) complexes of four new phenol based compartmental macrocyclic ligands, possessing contiguous (N2O2) and (NxO2) (x = 2, 3) coordination sites, were prepared by the template reaction of [N,N'-bis(3-formyl-5-ethylsalicylidene)ethane-1,2- diaminato]copper(II), with various di- and/or tri-amines in the presence of Pb(II) and Zn(II) ions. The crystal structure of [CuZnL3(H2O)](CiO(4))(2), 6, was determined by X-ray diffraction and shows that the Zn(II) and Cu(II) ions reside in the N2O2 sites of the macrocyclic ligand. The fifth coordination site of the Zn centre is occupied by a water ligand. All the complexes have been characterized by elemental analysis, molar conductivity and spectroscopic methods IR and UV). Also, all the synthesized complexes were screened for their antibacterial and antiftingal activity against Escherichia coli, Staphyloccocus aureus and Candida albicans. (C) 2007 Elsevier Ltd. All rights reserved.