Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?

被引：411

作者：

Johnstone, RW

Licht, JD

机构：

[1] Mt Sinai Sch Med, New York, NY 10029 USA

[2] Peter MacCallum Canc Ctr, Melbourne, Vic 3002, Australia

来源：

CANCER CELL | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1016/S1535-6108(03)00165-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：13 / 18

页数：6

共 30 条

[1] p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells [J].

Archer, SY ;

Meng, SF ;

Shei, A ;

Hodin, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6791-6796

[2] Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein [J].

Aron, JL ;

Parthun, MR ;

Marcucci, G ;

Kitada, S ;

Mone, AP ;

Davis, ME ;

Shen, TS ;

Murphy, T ;

Wickham, J ;

Kanakry, C ;

Lucas, DM ;

Reed, JC ;

Grever, MR ;

Byrd, JC .

BLOOD, 2003, 102 (02) :652-658

[3]

Burgess AJ, 2001, MOL PHARMACOL, V60, P828

[4] Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells [J].

Chen, ZX ;

Clark, S ;

Birkeland, M ;

Sung, CM ;

Lago, A ;

Liu, RG ;

Kirkpatrick, R ;

Johanson, K ;

Winkler, JD ;

Hu, ED .

CANCER LETTERS, 2002, 188 (1-2) :127-140

[5] Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment [J].

Daskalakis, M ;

Nguyen, TT ;

Nguyen, C ;

Guldberg, P ;

Köhler, G ;

Wijermans, P ;

Jones, PA ;

Lübbert, M .

BLOOD, 2002, 100 (08) :2957-2964

[6] Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor [J].

Di Croce, L ;

Raker, VA ;

Corsaro, M ;

Fazi, F ;

Fanelli, M ;

Faretta, M ;

Fuks, F ;

Lo Coco, F ;

Kouzarides, T ;

Nervi, C ;

Minucci, S ;

Pelicci, PG .

SCIENCE, 2002, 295 (5557) :1079-1082

[7]

Ferrara FF, 2001, CANCER RES, V61, P2

[8]

Glaser KB, 2003, MOL CANCER THER, V2, P151

[9] Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells [J].

Göttlicher, M ;

Minucci, S ;

Zhu, P ;

Krämer, OH ;

Schimpf, A ;

Giavara, S ;

Sleeman, JP ;

Lo Coco, F ;

Nervi, C ;

Pelicci, PG ;

Heinzel, T .

EMBO JOURNAL, 2001, 20 (24) :6969-6978

[10] Deacetylase enzymes: biological functions and the use of small-molecule inhibitors [J].

Grozinger, CM ;

Schreiber, SL .

CHEMISTRY & BIOLOGY, 2002, 9 (01) :3-16

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