Palladium-Catalyzed Dual C(sp2)-H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration: A Synthesis of Indolo[3,2-c]quinolinones

被引：21

作者：

Kong, Lingkai ^{[1
,2
]}

Zheng, Zhong ^{[1
]}

Tang, Rong ^{[1
]}

Wang, Mengdan ^{[1
]}

Sun, Yue ^{[1
]}

Li, Yanzhong ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

[2] Linyi Univ, Sch Chem & Chem Engn, Shuangling Rd, Linyi 276000, Shandong, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 18期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; EFFICIENT SYNTHESIS; BOND FUNCTIONALIZATION; DIRECT ARYLATION; INDOLES; ACTIVATION; CYCLIZATION; ALKYNES; INDOLOQUINOLINONES; (HETERO)ARENES;

D O I：

10.1021/acs.orglett.8b02419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Pd/Cu catalytic system to construct indolo[3,2-c]quinolinones has been developed starting from indole-2-carboxamides, Substrates were transformed into indolo[3,2-c]quinolinones through dual C(sp(2))-H functionalization of the indole moiety and arene, in which a carbonyl 1,2-migration was involved. The corresponding products were obtained in moderate to excellent yields with a wide substrate scope.

引用

页码：5696 / 5699

页数：4

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