Diaporisoindoles A-C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp SYSU-HQ3

被引：84
作者：
Cui, Hui [1 ]
Lin, Yun [2 ,3 ]
Luo, Mingchu [1 ]
Lu, Yongjun [2 ,3 ,4 ]
Huang, Xishan [1 ,4 ]
She, Zhigang [1 ,4 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Biomed Ctr, Guangzhou 510275, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510275, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 20期
基金：
中国国家自然科学基金;
关键词：
PROTEIN-TYROSINE PHOSPHATASES; MYCOBACTERIUM-TUBERCULOSIS; SELECTIVE INHIBITOR; NATURAL-PRODUCTS; MPTPB; POTENT; BEDAQUILINE; MACROPHAGES; RESISTANCE; DELAMANID;
D O I：
10.1021/acs.orglett.7b02748
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diaporisoindoles A (1) and B (2), two novel isoprenylisoindole alkaloids, and an unusual diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone C (4) were all isolated from the endophytic fungus Diaporthe sp. SYSU-HQ3. The absolute configurations of 1-4 were elucidated. by spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Diaporisoindole A (1) and tenellone C (4) exhibited inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B with IC50 values of 4.2 and 5.2 mu M.
引用
收藏
页码：5621 / 5624
页数：4
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