Diaporisoindoles A-C: Three Isoprenylisoindole Alkaloid Derivatives from the Mangrove Endophytic Fungus Diaporthe sp SYSU-HQ3

被引：84

作者：

Cui, Hui ^{[1
]}

Lin, Yun ^{[2
,3
]}

Luo, Mingchu ^{[1
]}

Lu, Yongjun ^{[2
,3
,4
]}

Huang, Xishan ^{[1
,4
]}

She, Zhigang ^{[1
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Biomed Ctr, Guangzhou 510275, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510275, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 20期

基金：

中国国家自然科学基金;

关键词：

PROTEIN-TYROSINE PHOSPHATASES; MYCOBACTERIUM-TUBERCULOSIS; SELECTIVE INHIBITOR; NATURAL-PRODUCTS; MPTPB; POTENT; BEDAQUILINE; MACROPHAGES; RESISTANCE; DELAMANID;

D O I：

10.1021/acs.orglett.7b02748

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diaporisoindoles A (1) and B (2), two novel isoprenylisoindole alkaloids, and an unusual diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone C (4) were all isolated from the endophytic fungus Diaporthe sp. SYSU-HQ3. The absolute configurations of 1-4 were elucidated. by spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Diaporisoindole A (1) and tenellone C (4) exhibited inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B with IC50 values of 4.2 and 5.2 mu M.

引用

页码：5621 / 5624

页数：4

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