Progranulin as a biomaker and potential therapeutic agent

被引：67

作者：

Abella, Vanessa ^{[1
,2
]}

Pino, Jesus ^{[3
]}

Scotece, Morena ^{[1
,2
]}

Conde, Javier ^{[1
,2
]}

Lagoa, Francisca ^{[4
,5
]}

Angel Gonzalez-Gay, Miguel ^{[6
,7
]}

Mera, Antonio ^{[8
]}

Gomez, Rodolfo ^{[1
,9
]}

Mobasheri, Ali ^{[10
,11
,12
]}

Gualillol, Oreste ^{[1
,2
]}

机构：

[1] Santiago Univ Clin Hosp, SERGAS Serv Galego Saude, Santiago De Compostela, Spain

[2] Santiago Univ Clin Hosp, IDIS Inst Invest Sanitaria Santiago, NEIRID Lab Neuroendocrine Interact Rheumatol & In, Res Lab 9, Santiago De Compostela, Spain

[3] Santiago Univ Clin Hosp, Div Orthopaed Surg & Traumatol, SERGAS Serv Galego Saude, Santiago De Compostela, Spain

[4] Santiago Univ Clin Hosp, CIBERCV Ctr Invest Biomed Red Enfermedades Cardio, Mol & Cellular Cardiol, Res Lab 7,SERGAS Serv Galego Saude, Bldg C,Travesia da Choupana S-N, Santiago De Compostela 15706, Spain

[5] Santiago Univ Clin Hosp, CIBERCV Ctr Invest Biomed Red Enfermedades Cardio, Mol & Cellular Cardiol, Res Lab 7,IDIS Inst Invest Sanitaria Santiago, Bldg C,Travesia da Choupana S-N, Santiago De Compostela 15706, Spain

[6] Univ Cantabria, Epidemiol Genet & Atherosclerosis Res Grp Syst In, Santander, Spain

[7] IDIVAL, Santander, Spain

[8] Santiago Univ Clin Hosp, Div Rheumatol, SERGAS Serv Galego Saude, Santiago De Compostela, Spain

[9] Santiago Univ Clin Hosp, IDIS Inst Invest Sanitaria Santiago, NEIRID Grp, Musculoskeletal Pathol Unit, Santiago De Compostela, Spain

[10] Univ Surrey, Sch Vet Med, Dept Vet Preclin Sci, Guildford, Surrey, England

[11] Univ Surrey, Fac Hlth & Med Sci, Duke Kent Bldg, Guildford GU2 7XH, Surrey, England

[12] Queens Med Ctr, Arthritis Res UK Ctr Sport Exercise & Osteoarthri, Nottingham NG7 2UH, England

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 10期

关键词：

GRANULIN-EPITHELIN PRECURSOR; GROWTH-FACTOR; BREAST-CANCER; PLASMA PROGRANULIN; CELL-PROLIFERATION; INSULIN-RESISTANCE; GP88; PROGRANULIN; TNF-ALPHA; EXPRESSION; ACROGRANIN;

D O I：

10.1016/j.drudis.2017.06.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Progranulin is a cysteine-rich secreted protein with diverse pleiotropic actions and participates in several processes, such as inflammation or tumorigenesis. Progranulin was first identified as a growth factor and, recently, it was characterised as an adipokine implicated in obesity, insulin resistance and rheumatic disease. At a central level, progranulin acts as a neurotropic and neuroprotective factor and protects from neural degeneration. In this review, we summarise the most recent research advances concerning the potential role of progranulin as a therapeutic target and biomarker in cancer, neurodegen erative and inflammatory diseases.

引用

页码：1557 / 1564

页数：8

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