Synergistic in vitro interactions between alpha interferon and ribavirin against bovine viral diarrhea virus and yellow fever virus as surrogate models of hepatitis C virus replication

被引：44

作者：

Buckwold, VE ^{[1
]}

Wei, JY ^{[1
]}

Wenzel-Mathers, M ^{[1
]}

Russell, J ^{[1
]}

机构：

[1] So Res Inst, Infect Dis Res Dept, Frederick, MD 21701 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 07期

关键词：

D O I：

10.1128/AAC.47.7.2293-2298.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use of the two antivirals together is much more efficacious. In vitro drug-drug combination analysis utilizing related members of the family Flaviviridae, bovine viral diarrhea virus and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.

引用

页码：2293 / 2298

页数：6

共 41 条

[1] Mechanism of action of a pestivirus antiviral compound [J].

Baginski, SG ;

Pevear, DC ;

Seipel, M ;

Sun, SCC ;

Benetatos, CA ;

Chunduru, SK ;

Rice, CM ;

Collett, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7981-7986

[2] Novel cell culture systems for the hepatitis C virus [J].

Bartenschlager, R ;

Lohmann, V .

ANTIVIRAL RESEARCH, 2001, 52 (01) :1-17

[3]

Blight K.J., 2002, HEPATITIS VIRUSES, P81

[4] Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial [J].

Bodenheimer, HC ;

Lindsay, KL ;

Davis, GL ;

Lewis, JH ;

Thung, SN ;

Seeff, LB .

HEPATOLOGY, 1997, 26 (02) :473-477

[5] Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro [J].

Castet, V ;

Fournier, C ;

Soulier, A ;

Brillet, R ;

Coste, J ;

Larrey, D ;

Dhumeaux, D ;

Maurel, P ;

Pawlotsky, JM .

JOURNAL OF VIROLOGY, 2002, 76 (16) :8189-8199

[6] Comparative analysis of anti-hepatitis C virus activity and gene expression mediated by alpha, beta, and gamma interferons [J].

Cheney, IW ;

Lai, VCH ;

Zhong, WD ;

Brodhag, T ;

Dempsey, S ;

Lim, C ;

Hong, Z ;

Lau, JYN ;

Tam, RC .

JOURNAL OF VIROLOGY, 2002, 76 (21) :11148-11154

[7] Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system [J].

Contreras, AM ;

Hiasa, Y ;

He, WP ;

Terella, A ;

Schmidt, EV ;

Chung, RT .

JOURNAL OF VIROLOGY, 2002, 76 (17) :8505-8517

[8] The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen [J].

Crotty, S ;

Maag, D ;

Arnold, JJ ;

Zhong, WD ;

Lau, JYN ;

Hong, Z ;

Andino, R ;

Cameron, CE .

NATURE MEDICINE, 2000, 6 (12) :1375-1379

[9] RNA virus error catastrophe: Direct molecular test by using ribavirin [J].

Crotty, S ;

Cameron, CE ;

Andino, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6895-6900

[10] RIBAVIRIN AS THERAPY FOR CHRONIC HEPATITIS-C - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

DIBISCEGLIE, AM ;

CONJEEVARAM, HS ;

FRIED, MW ;

SALLIE, R ;

PARK, Y ;

YURDAYDIN, C ;

SWAIN, M ;

KLEINER, DE ;

MAHANEY, K ;

HOOFNAGLE, JH ;

WRIGHT, D .

ANNALS OF INTERNAL MEDICINE, 1995, 123 (12) :897-&

← 1 2 3 4 5 →