Neutropenia and febrile neutropenia are two major complications of chemotherapy. Dose reductions, delays in treatment administration, and the use of granulocyte colony-stimulating factors are equally recommended options to preserve absolute neutrophil count in case of chemotherapy regimens bringing a risk of febrile neutropenia of 20% or higher. Recombinant granulocyte colony-stimulating factors, such as filgrastim and lenograstim, have a short elimination half-life (t(1/2)) and need to be used daily, while others, like pegfilgrastim and lipegfilgrastim, are characterized by a long t(1/2) requiring only a single administration per cycle. Balugrastim is a novel long-acting recombinant granulocyte colony-stimulating factor obtained by means of a genetic fusion between recombinant human serum albumin and granulocyte colony-stimulating factor. Albumin binding increases the molecular weight and determines a high plasmatic stability leading to a t(1/2) of similar to 19 days. Balugrastim's efficacy, safety, and tolerability have been assessed in four different clinical trials involving breast cancer patients treated with doxorubicin and docetaxel. Pegfilgrastim was chosen as a comparator. Balugrastim was noninferior to pegfilgrastim with regard to the reduction of mean duration of severe neutropenia during cycle 1. Moreover, both treatments were comparable in terms of efficacy and safety profile. Balugrastim was well tolerated, with the only related adverse event being mild to moderate bone pain. The aim of this review is to summarize the currently available literature data on balugrastim.
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Univ S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Univ S Carolina, South Carolina Coll Pharm, Southern Network Adverse React SONAR, Columbia, SC 29208 USA
Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
William Jennings Bryan Dorn Vet Affairs Med Ctr, Columbia, SC USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Bennett, Charles L.
Djulbegovic, Benjamin
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Univ S Florida, Morsani Coll Med, Ctr Evidence Based Med & Hlth Outcome Res, Clin & Translat Sci Inst,Dept Med, Tampa, FL USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Hematol, Tampa, FL USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Hlth Outcomes & Behav, Tampa, FL USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Djulbegovic, Benjamin
Norris, LeAnn B.
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Univ S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Univ S Carolina, South Carolina Coll Pharm, Southern Network Adverse React SONAR, Columbia, SC 29208 USA
Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
William Jennings Bryan Dorn Vet Affairs Med Ctr, Columbia, SC USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Norris, LeAnn B.
Armitage, James O.
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Univ Nebraska, Omaha Sch Med, Omaha, NE 68182 USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
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Univ Melbourne, Parkville, Vic 3052, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Eyles, Jo L.
Hickey, Michael J.
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Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Hickey, Michael J.
Norman, M. Ursula
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Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Norman, M. Ursula
Croker, Ben A.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Croker, Ben A.
Roberts, Andrew W.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Roberts, Andrew W.
Drake, Sarah F.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Drake, Sarah F.
James, Will G.
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Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
James, Will G.
Metcalf, Donald
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Metcalf, Donald
Campbell, Ian K.
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Campbell, Ian K.
Wicks, Ian P.
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
机构:
Univ S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Univ S Carolina, South Carolina Coll Pharm, Southern Network Adverse React SONAR, Columbia, SC 29208 USA
Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
William Jennings Bryan Dorn Vet Affairs Med Ctr, Columbia, SC USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Bennett, Charles L.
Djulbegovic, Benjamin
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, Morsani Coll Med, Ctr Evidence Based Med & Hlth Outcome Res, Clin & Translat Sci Inst,Dept Med, Tampa, FL USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Hematol, Tampa, FL USA
H Lee Moffitt Canc Ctr & Res Inst, Dept Hlth Outcomes & Behav, Tampa, FL USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Djulbegovic, Benjamin
Norris, LeAnn B.
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机构:
Univ S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Univ S Carolina, South Carolina Coll Pharm, Southern Network Adverse React SONAR, Columbia, SC 29208 USA
Med Univ S Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
William Jennings Bryan Dorn Vet Affairs Med Ctr, Columbia, SC USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
Norris, LeAnn B.
Armitage, James O.
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h-index: 0
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Univ Nebraska, Omaha Sch Med, Omaha, NE 68182 USAUniv S Carolina, South Carolina Coll Pharm, South Carolina Ctr Econ Excellence Medicat Safety, Columbia, SC 29208 USA
机构:
Univ Melbourne, Parkville, Vic 3052, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Eyles, Jo L.
Hickey, Michael J.
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h-index: 0
机构:
Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Hickey, Michael J.
Norman, M. Ursula
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Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Norman, M. Ursula
Croker, Ben A.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Croker, Ben A.
Roberts, Andrew W.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Roberts, Andrew W.
Drake, Sarah F.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Drake, Sarah F.
James, Will G.
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机构:
Monash Univ, Ctr Inflammatory Dis, Clayton, Vic 3800, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
James, Will G.
Metcalf, Donald
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Metcalf, Donald
Campbell, Ian K.
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机构:Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia
Campbell, Ian K.
Wicks, Ian P.
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Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Reid Rheumatol Lab, Div Autoimmun & Transplantat, Parkville, Vic 3050, Australia