Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats

被引：77
作者：
Yadav, Rajesh S. [1 ]
Shukla, Rajendra K. [1 ]
Sankhwar, Madhu Lata [1 ]
Patel, Devendra K. [1 ]
Ansari, Reyaz W. [1 ]
Pant, Aditya B. [1 ]
Islam, Fakhrul [2 ]
Khanna, Vinay K. [1 ]
机构：
[1] Indian Inst Toxicol Res, Lucknow 226001, Uttar Pradesh, India
[2] Dept Med Elernentol & Toxicol, Neurotoxicol Lab, New Delhi 110062, India
来源：
NEUROTOXICOLOGY | 2010年 / 31卷 / 05期
关键词：
Arsenic; Rat brain; Catecholamine; Nitric oxide; Curcumin; Neuroprotection; NITRIC-OXIDE SYNTHASE; INDUCED OXIDATIVE STRESS; FOCAL CEREBRAL-ISCHEMIA; KAPPA-B ACTIVATION; MANGANESE COMPLEXES; LIPID-PEROXIDATION; AMYLOID PATHOLOGY; CENTELLA-ASIATICA; BIOGENIC-AMINES; IN-VIVO;
D O I：
10.1016/j.neuro.2010.05.001
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Our recent studies have shown that arsenic-induced neurobehavioral toxicity is protected by curcumin by modulating oxidative stress and dopaminergic functions in rats. In addition, the neuroprotective effect of curcumin has been investigated on arsenic-induced alterations in biogenic amines, their metabolites and nitric oxide (NO), which play an important role in neurotransmission process. Decrease in the levels of dopamine (DA, 28%), norepinephrine (NE, 54%), epinephrine (EPN, 46%), serotonin (5-HT, 44%), 3,4-dihydroxyphenylacetic acid (DOPAC, 20%) and homovanillic acid (HVA, 31%) in corpus striatum; DA (51%), NE (22%), EPN (47%), 5-HT (25%), DOPAC (34%) and HVA (41%) in frontal cortex and DA (35%), NE (35%), EPN (29%), 5-HT (54%), DOPAC (37%) and HVA (46%) in hippocampus, observed in arsenic (sodium arsenite, 20 mg/kg body weight, p.o., 28 days) treated rats exhibited a trend of recovery in rats simultaneously treated with arsenic and curcumin (100 mg/kg body weight, p.o., 28 days). Increased levels of NO in corpus striatum (2.4-fold), frontal cortex (6.1-fold) and hippocampus (6.2-fold) in arsenic-treated rats were found decreased in rats simultaneously treated with arsenic and curcumin. It is evident that curcumin modulates levels of brain biogenic amines and NO in arsenic-exposed rats and these results further strengthen its neuroprotective efficacy. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：533 / 539
页数：7
相关论文
共 106 条
[21]   Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats [J].
Das, Anup K. ;
Bag, Sujit ;
Sahu, Ranabir ;
Dua, Tarun K. ;
Sinha, Mohit K. ;
Gangopadhyay, Moumita ;
Zaman, Kamaruz ;
Dewanjee, Saikat .
FOOD AND CHEMICAL TOXICOLOGY, 2010, 48 (01) :326-335
[22]   Effects of arsenite on central monoamines and plasmatic levels of adrenocorticotropic hormone (ACTH) in mice [J].
Delgado, JM ;
Dufour, L ;
Grimaldo, JI ;
Carrizales, L ;
Rodríguez, VM ;
Jiménez-Capdeville, ME .
TOXICOLOGY LETTERS, 2000, 117 (1-2) :61-67
[23]   Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs [J].
El-Demerdash, Fatma M. ;
Yousef, Mokhtar I. ;
Radwan, Fatma M. E. .
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (01) :249-254
[24]   NO as a signalling molecule in the nervous system [J].
Esplugues, JV .
BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (05) :1079-1095
[25]   Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats [J].
Flora, S. J. S. ;
Gupta, Richa .
PHYTOTHERAPY RESEARCH, 2007, 21 (10) :980-988
[26]   Arsenic moiety in gallium arsenide is responsible for neuronal apoptosis and behavioral alterations in rats [J].
Flora, Swaran J. S. ;
Bhatt, Kapil ;
Mehta, Ashish .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 240 (02) :236-244
[27]   Drugs, Biogenic Amine Targets and the Developing Brain [J].
Frederick, Aliya L. ;
Stanwood, Gregg D. .
DEVELOPMENTAL NEUROSCIENCE, 2009, 31 (1-2) :7-22
[28]   Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease [J].
Gao, HM ;
Jiang, J ;
Wilson, B ;
Zhang, W ;
Hong, JS ;
Liu, B .
JOURNAL OF NEUROCHEMISTRY, 2002, 81 (06) :1285-1297
[29]   Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model [J].
Garcia-Alloza, M. ;
Borrelli, L. A. ;
Rozkalne, A. ;
Hyman, B. T. ;
Bacskai, B. J. .
JOURNAL OF NEUROCHEMISTRY, 2007, 102 (04) :1095-1104
[30]   REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN [J].
GLOWINSKI, J ;
IVERSEN, LL .
JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) :655-+
12345678910