APC/C-Cdh1 From cell cycle to cellular differentiation and genomic integrity

被引：77
作者：
Qiao, Xinxian
Zhang, Liyong
Gamper, Armin M.
Fujita, Takeo
Wan, Yong [1 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15260 USA
来源：
CELL CYCLE | 2010年 / 9卷 / 19期
关键词：
APC/C; Cdh1; proteolysis; genomic integrity; signal transduction; differentiation; tumorigenesis; ANAPHASE-PROMOTING COMPLEX; DNA-REPLICATION; CDH1; DEGRADATION; PROTEOLYSIS; ACTIVATION; STABILITY; MITOSIS; PATHWAY; PROTEIN;
D O I：
10.4161/cc.9.19.13585
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two WD-40 domain proteins, Cdc20 and Cdh1. While APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. In the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases.
引用
收藏
页码：3904 / 3912
页数：9
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