Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population

被引：43
作者：
Vepsalainen, Saila
Parkinson, Michele
Helisalmi, Seppo
Mannermaa, Arto
Soininen, Hilkka
Tanzi, Rudolph E.
Bertram, Lars
Hiltunen, Mikko
机构：
[1] Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
[3] Univ Kuopio, Clin Res Ctr Mediteknia, Brain Res Unit, FIN-70211 Kuopio, Finland
[4] Massachusetts Gen Hosp, Dept Neurol, MassGen Inst Neurodegenerat Dis, Genet & Aging Res Unit, Charlestown, MA USA
[5] Kuopio Univ Hosp, Dept Pathol, SF-70210 Kuopio, Finland
来源：
JOURNAL OF MEDICAL GENETICS | 2007年 / 44卷 / 09期
关键词：
D O I：
10.1136/jmg.2006.048470
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer's disease (AD) based on its ability to degrade amyloid beta-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
引用
收藏
页码：606 / 608
页数：3
相关论文
共 50 条
  • [21] The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population
    Cui, Pei-Jing
    Cao, Li
    Wang, Ying
    Deng, Yu-Lei
    Xu, Wei
    Wang, Gang
    Zhang, Yu
    Zheng, Lan
    Fei, Qing-Zhou
    Zhang, Ting
    Chen, Sheng-Di
    JOURNAL OF CLINICAL NEUROSCIENCE, 2012, 19 (05) : 745 - 749
  • [22] Insulin-Degrading Enzyme: A Link Between Alzheimer's and Type 2 Diabetes Mellitus
    Haque, Rizwanul
    Nazir, Aamir
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2014, 13 (02) : 259 - 264
  • [23] Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme´s implication for Alzheimer´s disease pathology?
    Hans-Gert Bernstein
    Gerburg Keilhoff
    Henrik Dobrowolny
    Johann Steiner
    European Archives of Psychiatry and Clinical Neuroscience, 2020, 270 : 495 - 496
  • [24] Binding varicella zoster virus: an underestimated facet of insulin-degrading enzyme's implication for Alzheimer's disease pathology?
    Bernstein, Hans-Gert
    Keilhoff, Gerburg
    Dobrowolny, Henrik
    Steiner, Johann
    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2020, 270 (04) : 495 - 496
  • [25] Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-ε4 allele
    Cook, DG
    Leverenz, JB
    McMillan, PJ
    Kulstad, JJ
    Ericksen, S
    Roth, RA
    Schellenberg, GD
    Jin, LW
    Kovacina, KS
    Craft, S
    AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (01) : 313 - 319
  • [26] FOLLOW UP OF COGNITIVE DEFICITS AND INSULIN-DEGRADING ENZYME EXPRESSION IN A RAT MODEL OF SPORADIC ALZHEIMER'S DISEASE
    Knezovic, A.
    Osmanovic-Barilar, J.
    Gruenblatt, E.
    Riederer, P.
    Salkovic-Petrisic, M.
    JOURNAL OF NEUROCHEMISTRY, 2011, 118 : 138 - 138
  • [27] No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
    Sakai, A
    Ujike, H
    Nakata, K
    Takehisa, Y
    Imamura, T
    Uchida, N
    Kanzaki, A
    Yamamoto, M
    Fujisawa, Y
    Okumura, K
    Kuroda, S
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 125B (01) : 87 - 91
  • [28] Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme
    Gonzalez-Casimiro, Carlos M.
    Merino, Beatriz
    Casanueva-Alvarez, Elena
    Postigo-Casado, Tamara
    Camara-Torres, Patricia
    Fernandez-Diaz, Cristina M.
    Leissring, Malcolm A.
    Cozar-Castellano, Irene
    Perdomo, German
    BIOMEDICINES, 2021, 9 (01) : 1 - 38
  • [29] Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease
    Wang, Shitao
    He, Feiyan
    Wang, Ying
    JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2015, 28 (02) : 94 - 98
  • [30] Targeting Insulin-Degrading Enzyme in Insulin Clearance
    Leissring, Malcolm A.
    Gonzalez-Casimiro, Carlos M.
    Merino, Beatriz
    Suire, Caitlin N.
    Perdomo, German
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (05) : 1 - 21
12345