The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer

被引：35

作者：

Jiang, Weiliang ^{[1
]}

Zhao, Senlin ^{[2
]}

Xu, Ling ^{[3
]}

Lu, Yingying ^{[1
]}

Lu, Zhanjun ^{[1
]}

Chen, Congying ^{[1
]}

Ni, Jianbo ^{[1
]}

Wan, Rong ^{[1
]}

Yang, Lijuan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Gastroenterol, Shanghai 200080, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Gen Surg, Shanghai 200080, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Dept Gastroenterol, Shanghai 200080, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 73卷

基金：

中国国家自然科学基金;

关键词：

Xanthohumol; Pancreatic cancer; STAT3; signaling; CONFERS RESISTANCE; SIGNAL TRANSDUCER; APOPTOSIS; STAT3; ACTIVATION; GEMCITABINE; EXPRESSION; PATHWAY; SAFETY;

D O I：

10.1016/j.biopha.2015.05.020

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pancreatic cancer (PC) is one of the most lethal human malignancies worldwide. Here, we demonstrated that xanthohumol (XN), the most abundant prenylated chalcone isolated from hops, inhibited the growth of cultured PC cells and their subcutaneous xenograft tumors. XN treatment was found to induce cell cycle arrest and apoptosis of PC cells (PANC-1, BxPC-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3) and expression of its downstream targeted genes cyclinD1, survivin, and Bcl-xL at the messenger RNA level, which involved in regulation of apoptosis and the cell cycle. Overall, our results suggested that XN presents a promising candidate therapeutic agent against human PC and the STAT3 signaling pathway is its key molecular target. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：40 / 47

页数：8

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