Immune Response to SARS-CoV-2 Vaccine and Following Breakthrough Omicron Infection in an Autoimmune Patient with Hashimoto's Thyroiditis, Pernicious Anemia, and Chronic Atrophic Autoimmune Gastritis: A Case Report

被引：1

作者：

Cluff, Emily ^{[1
]}

Bellusci, Lorenza ^{[1
]}

Golding, Hana ^{[1
]}

Khurana, Surender ^{[1
]}

机构：

[1] US FDA, Ctr Biol Evaluat & Res CBER, Div Viral Prod, Silver Spring, MD 20993 USA

来源：

VACCINES | 2022年 / 10卷 / 03期

关键词：

COVID-19; Omicron; SARS-CoV-2; neutralization; autoimmune; Hashimoto's; vaccine; mRNA; breakthrough;

D O I：

10.3390/vaccines10030450

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In healthy adults, hybrid immunity induced by prior SARS-CoV-2 infection followed by two doses of mRNA vaccination provide protection against symptomatic SARS-CoV-2 infection. However, the role of hybrid immunity in autoimmune patients against Omicron is not well documented. Here, we report a young autoimmune patient with prior infection and two doses of mRNA-1273 vaccination who was exposed to Omicron and developed a symptomatic disease. Prior to Omicron infection, the patient had strong neutralizing antibody titers against the vaccine strain, but no neutralization of Omicron. Post Omicron infection, high neutralizing titers against Omicron were observed. Furthermore, enhanced neutralizing antibody titers against other variants of concern-Alpha, Beta, Gamma, and Delta-were observed, suggesting an expansion of cross-reactive memory B-cell response by the SARS-CoV-2 Omicron infection. Autoimmune patients may require careful monitoring of immune function over time to optimize booster vaccine administration.

引用

页数：6

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