Severe fever with thrombocytopenia syndrome: a newly discovered emerging infectious disease

被引:90
作者
Li, D. X. [1 ]
机构
[1] China CDC, Natl Inst Viral Dis Control & Prevent, Key Lab Med Virol, Beijing 102206, Peoples R China
关键词
Clinical; epidemiology; SFTS virus; SFTS; virology; SYNDROME VIRUS-INFECTION; TO-PERSON TRANSMISSION; SYNDROME BUNYAVIRUS; HEMORRHAGIC-FEVER; SFTS BUNYAVIRUS; RISK-FACTORS; IDENTIFICATION; CHINA; PATHOGENESIS; INTERFERON;
D O I
10.1016/j.cmi.2015.03.001
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered emerging infectious disease that has recently become epidemic in Asia. The causative agent of SFTS is a novel phlebovirus in the family Bunyaviridae, designated SFTS virus (SFTSV). SFTS clinically presents with high fever, thrombocytopenia, leukocytopenia, gastrointestinal disorders, and multi-organ dysfunction, with a high viral load and a high case-fatality rate. In human infection, SFTSV targets microphages, replicates in the spleen of infected mice, and causes thrombocytopenia and a cytokine storm. The tick disseminates virus to humans and animals, forming a special transmission model in nature. Person-to-person transmission though direct contact with patient blood has been frequently reported. Measurements of viral RNA and antibodies have been established for diagnosis, but vaccines and specific therapeutics are not available so far. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:614 / 620
页数:7
相关论文
共 68 条
[1]   A Family Cluster of Infections by a Newly Recognized Bunyavirus in Eastern China, 2007: Further Evidence of Person-to-Person Transmission [J].
Bao, Chang-jun ;
Guo, Xi-ling ;
Qi, Xian ;
Hu, Jian-li ;
Zhou, Ming-hao ;
Varma, Jay K. ;
Cui, Lun-biao ;
Yang, Hai-tao ;
Jiao, Yong-jun ;
Klena, John D. ;
Li, Lu-xun ;
Tao, Wen-yuan ;
Li, Xian ;
Chen, Yin ;
Zhu, Zheng ;
Xu, Ke ;
Shen, Ai-hua ;
Wu, Tao ;
Peng, Hai-yan ;
Li, Zhi-feng ;
Shan, Jun ;
Shi, Zhi-yang ;
Wang, Hua .
CLINICAL INFECTIOUS DISEASES, 2011, 53 (12) :1208-1214
[2]  
Bao CJ, 2011, NEW ENGL J MED, V365, P862, DOI 10.1056/NEJMc1106000
[3]   A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus [J].
Chen, Hongbin ;
Hu, Ke ;
Zou, Jinjing ;
Xiao, Jinxiu .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2013, 17 (03) :E206-E208
[4]  
Chen Ze, 2008, Sichuan Journal of Zoology, V27, P820
[5]  
Chi Y, 2012, J SHANDONG U HLTH SC, V50, P119
[6]   Detection of Severe Fever with Thrombocytopenia Syndrome Virus by Reverse Transcription-Cross-Priming Amplification Coupled with Vertical Flow Visualization [J].
Cui, Lunbiao ;
Ge, Yiyue ;
Qi, Xian ;
Xu, Gaolian ;
Li, Haijing ;
Zhao, Kangchen ;
Wu, Bin ;
Shi, Zhiyang ;
Guo, Xiling ;
Hu, Lin ;
You, Qimin ;
Zhang, Li-Hong ;
Freiberg, Alexander N. ;
Yu, Xuejie ;
Wang, Hua ;
Zhou, Minghao ;
Tang, Yi-Wei .
JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (12) :3881-3885
[7]   Clinical Features and Factors Associated with Severity and Fatality among Patients with Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection in Northeast China [J].
Deng, Baocheng ;
Zhou, Bo ;
Zhang, Shujun ;
Zhu, Ying ;
Han, Leqiang ;
Geng, Yingzhi ;
Jin, Zhenan ;
Liu, Hongbo ;
Wang, Donglei ;
Zhao, Yitong ;
Wen, Ying ;
Cui, Wei ;
Zhou, Ying ;
Gu, Qiuhong ;
Sun, Cuiming ;
Lu, Xu ;
Wang, Wen ;
Wang, Yu ;
Li, Chengbo ;
Wang, Yanli ;
Yao, Wenqing ;
Liu, Pei .
PLOS ONE, 2013, 8 (11)
[8]   Acute Thrombocytopenia, Leucopenia, and Multiorgan Dysfunction: The First Case of SFTS Bunyavirus outside China? [J].
Denic, Srdjan ;
Janbeih, Joumana ;
Nair, Suresh ;
Conca, Walter ;
Tariq, Waheed Uz Zaman ;
Al-Salam, Suhail .
CASE REPORTS IN INFECTIOUS DISEASES, 2011, 2011
[9]   Identification of two severe fever with thrombocytopenia syndrome virus strains originating from reassortment [J].
Ding, Nai-Zheng ;
Luo, Zhi-Fei ;
Niu, Dan-Dan ;
Ji, Wei ;
Kang, Xiu-Han ;
Cai, Si-Si ;
Xu, Dong-Shuai ;
Wang, Qiu-Wen ;
He, Cheng-Qiang .
VIRUS RESEARCH, 2013, 178 (02) :543-546
[10]   Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection [J].
Ding, Y-P. ;
Liang, M-F. ;
Ye, J-b. ;
Liu, Q-h. ;
Xiong, C-h. ;
Long, B. ;
Lin, W-b. ;
Cui, N. ;
Zou, Z-q. ;
Song, Y-l. ;
Zhang, Q-f. ;
Zhang, S. ;
Liu, Y-z. ;
Song, G. ;
Ren, Y-y. ;
Li, S-h. ;
Wang, Y. ;
Hou, F-q. ;
Yu, H. ;
Ding, P. ;
Ye, F. ;
Li, D-X. ;
Wang, G-Q. .
CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (11) :O870-O878