Balance of transforming growth factor-β1 and platelet-derived growth factor-BB is associated with kidney allograft rejection

被引：3

作者：

Pozzetto, Ubaldo ^{[1
]}

Abeni, Damiano ^{[2
]}

Citterio, Franco ^{[3
]}

Castagneto, Marco ^{[3
]}

Capogrossi, Maurizio C. ^{[2
]}

Facchiano, Antonio ^{[2
]}

机构：

[1] IASI CNR, I-00168 Rome, Italy

[2] IDI IRCCS, Inst Dermopat Immacolata, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dipartimento Chirurg, Rome, Italy

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2008年 / 45卷

关键词：

D O I：

10.1258/acb.2007.007155

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: About 50% of kidney-transplant patients undergo organ rejection within 10 years. Chronic allograft nephropathy (CAN) represents the dominant cause of kidney transplant failure and accounts for 50-80% of graft loss in long-term surviving patients. CAN pathogenesis is multifactorial and not-completely elucidated; several reports indicate TGF-beta 1 and platelet-derived growth factor (PDGF)-BB expression in CAN suggesting a possible role of these factors in the allograft arteriosclerosis and graft failure. Methods: We investigated the plasma expression concentrations of human growth factors with enzyme-linked immunosorbent assays and appropriate statistical analysis. Results: We present evidences showing statistically significant association of CAN with a specific balance between TGF Beat1 and PDGF-BB plasma concentrations, in 129 kidney-transplant patients and 15 healthy controls. Odds ratios were computed to correlate expression-levels with CAN occurrence. Conclusion: We believe these data may suggest a novel non-invasive method to identify early molecular markers of graft deterioration.

引用

页码：213 / 214

页数：2

共 6 条

[1] Relationship between subclinical rejection and genotype, renal messenger RNA, and plasma protein transforming growth factor-β1 levels [J].