Copper catalyzed/mediated direct B-H alkenylation/alkynylation in carboranes

被引：55

作者：

Chen, Yu ^{[1
,2
]}

Au, Yik Ki ^{[1
,2
]}

Quan, Yangjian ^{[1
]}

Xie, Zuowei ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2019年 / 62卷 / 01期

关键词：

4+2] annulation; alkynylation; B-H activation; base metal catalysis; carborane; METAL-PROMOTED REACTIONS; O-CARBORANES; COUPLING REACTIONS; BORON CLUSTERS; DRUG DISCOVERY; FUNCTIONALIZATION; BONDS; ACTIVATION; ALKENE; ANIONS;

D O I：

10.1007/s11426-018-9388-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Base metal catalyzed regioselective cage B-H functionalization has been achieved. Under the assistance of a bidentate directing group, Cu-catalyzed [4+2] annulation of carboranyl amides with internal alkynes affords unprecedented C,B-substituted carborane-fused-pyridone derivatives, whereas the use of terminal alkynes leads to B-H/C(sp)-H dehydrocoupling products. The isolation and structural identification of a notably stable Cu(I) intermediate shed light on the reaction mechanism, which is proposed to involve a Cu(III) intermediate.

引用

页码：74 / 79

页数：6

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