Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF

被引：46

作者：

Obiang, Pauline ^{[1
]}

Maubert, Eric ^{[1
]}

Bardou, Isabelle ^{[1
]}

Nicole, Olivier ^{[2
]}

Launay, Severine ^{[3
]}

Bezin, Laurent ^{[4
,5
]}

Vivien, Denis ^{[1
]}

Agin, Veronique ^{[1
]}

机构：

[1] Univ Caen Basse Normandie, CNRS, INSERM,Serine Proteases & Pathophysiol Neurovasc, CI NAPS,GIP CYCERON,UMR 6232,U919,SP2U, F-14074 Caen, France

[2] UCBN, GIP CYCERON, CI NAPS, CNRS,UMR 6232,PSY, F-14074 Caen, France

[3] Univ Edinburgh, Ctr Cognit & Neural Syst, Edinburgh EH8 9JZ, Midlothian, Scotland

[4] Univ Lyon 1, CNRS, Integrat Cellular & Mol Physiol Lab, UMR 5123, F-69622 Villeurbanne, France

[5] Univ Lyon, F-69003 Lyon, France

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 02期

关键词：

Aging; Tissue type plasminogen activator; Brain derived neurotrophic factor; Long-term environmental enrichment; Emotional memory; Spatial memory; TISSUE-PLASMINOGEN-ACTIVATOR; LONG-TERM POTENTIATION; ENVIRONMENTAL ENRICHMENT; SPATIAL MEMORY; HIPPOCAMPAL NEUROGENESIS; MICROGLIAL ACTIVATION; SYNAPTIC PLASTICITY; NEUROTROPHIN LEVELS; NMDA RECEPTORS; MICE LACKING;

D O I：

10.1016/j.nlm.2011.03.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA-BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：121 / 129

页数：9

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