Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF

被引：46
作者：
Obiang, Pauline [1 ]
Maubert, Eric [1 ]
Bardou, Isabelle [1 ]
Nicole, Olivier [2 ]
Launay, Severine [3 ]
Bezin, Laurent [4 ,5 ]
Vivien, Denis [1 ]
Agin, Veronique [1 ]
机构：
[1] Univ Caen Basse Normandie, CNRS, INSERM,Serine Proteases & Pathophysiol Neurovasc, CI NAPS,GIP CYCERON,UMR 6232,U919,SP2U, F-14074 Caen, France
[2] UCBN, GIP CYCERON, CI NAPS, CNRS,UMR 6232,PSY, F-14074 Caen, France
[3] Univ Edinburgh, Ctr Cognit & Neural Syst, Edinburgh EH8 9JZ, Midlothian, Scotland
[4] Univ Lyon 1, CNRS, Integrat Cellular & Mol Physiol Lab, UMR 5123, F-69622 Villeurbanne, France
[5] Univ Lyon, F-69003 Lyon, France
来源：
NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 02期
关键词：
Aging; Tissue type plasminogen activator; Brain derived neurotrophic factor; Long-term environmental enrichment; Emotional memory; Spatial memory; TISSUE-PLASMINOGEN-ACTIVATOR; LONG-TERM POTENTIATION; ENVIRONMENTAL ENRICHMENT; SPATIAL MEMORY; HIPPOCAMPAL NEUROGENESIS; MICROGLIAL ACTIVATION; SYNAPTIC PLASTICITY; NEUROTROPHIN LEVELS; NMDA RECEPTORS; MICE LACKING;
D O I：
10.1016/j.nlm.2011.03.004
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA-BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions. (C) 2011 Elsevier Inc. All rights reserved.
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收藏
页码：121 / 129
页数：9
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