Role of Axonal Guidance Factor Netrin-1 in Human Placental Vascular Growth

被引：9

作者：

Wang, Qianhua ^{[1
]}

Zhu, Jianwen ^{[1
]}

Zou, Li ^{[1
]}

Yang, Yun ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Gynecol & Obstet, Union Hosp, Wuhan 430022, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2011年 / 31卷 / 02期

关键词：

netrin-1; placenta; pregnancy; vascular development; MICROVASCULAR ENDOTHELIAL-CELLS; THERAPEUTIC ANGIOGENESIS; APOPTOSIS; RECEPTORS;

D O I：

10.1007/s11596-011-0261-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study investigated the role of netrin-1 in placental vascular development. In vitro rat aortic ring assay and in vivo Matrigel plug assay were conducted to exmaine the effect of netrin-1 on angiogenesis. Human placental microvascular endothelial cells (HPMECs) were isolated and cultured and their viability, migration and tubular formation were studied, in order to examine the effects of netrin-1. The results showed that netrin-1 potently stimulated neovascularization in a mouse Matrigel plug in vivo and the sprouting of endothelial cells in rat aortic rings in vitro. In addition, netrin-1 enhanced the viability, migration and tube formation of HPMECs. Our study suggested that netrin-1 could significantly promote the formation of blood vessels of human placenta and may be a potential target for developing new therapeutic strategies for placental vasculature-related diseases.

引用

页码：246 / 250

页数：5

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