m6A: Signaling for mRNA splicing

被引：115

作者：

Adhikari, Samir ^{[1
]}

Xiao, Wen ^{[1
]}

Zhao, Yong-Liang ^{[2
]}

Yang, Yun-Gui ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Beijing Inst Genom, CAS Ctr Excellence Mol Cell Sci,Chinese Acad Sci, Key Lab Genom & Precis Med,Collaborat Innovat Ctr, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, Beijing Inst Genom, Chinese Acad Sci, Key Lab Genom & Precis Med,China Gastrointestinal, Beijing, Peoples R China

来源：

RNA BIOLOGY | 2016年 / 13卷 / 09期

关键词：

Alternative splicing; m(6)A; SRSF3; SRSF10; YTHDC1; YTH DOMAIN; NUCLEAR-RNA; METHYLATION; N6-METHYLADENOSINE; TRANSLATION; YT521-B; BINDING;

D O I：

10.1080/15476286.2016.1201628

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among myriads of distinct chemical modifications in RNAs, dynamic N6-methyladenosine (m(6)A) is one of the most prevalent modifications in eukaryotic mRNAs and non-coding RNAs. Similar to the critical role of chemical modifications in regulation of DNA and protein activities, RNA m(6)A modification is also observed to be involved in the regulation of diverse functions of RNAs including meiosis, fertility, development, cell reprogramming and circadian period. The RNA m(6)A modification is recognized by YTH domain containing family proteins comprising of YTHDC1-2 and YTHDF1-3. Here we focus on the nuclear m(6)A reader YTHDC1 and its regulatory role in alternative splicing and other RNA metabolic processes.

引用

页码：756 / 759

页数：4

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