Release of diclofenac through gluteraldehyde crosslinked poly(vinyl alcohol)/poly(acrylic acid) alloy membranes

被引：22

作者：

Sanli, O ^{[1
]}

Asman, G ^{[1
]}

机构：

[1] Gazi Univ, Fac Art & Sci, Dept Chem, TR-06500 Ankara, Turkey

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2004年 / 91卷 / 01期

关键词：

diclofenac; membranes; drug delivery systems; hydrophilic polymers; water-soluble polymers;

D O I：

10.1002/app.13102

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A controlled-release preparation of diclofenac sodium for transdermal administration has been developed. Poly(vinyl alcohol) (PVA) and PVA/poly(acrylic acid) (PAA) alloy membranes were prepared from a solvent-casting technique using different PVA/PAA (v/v) ratios. The release of the drug from the membrane was evaluated under in vitro conditions at pH 7.4. The delivery system provided linear release without time lag, burst effect, and boundary layer resistance. Effects of variables such as film thickness and PVA/PAA ratio on the permeation behavior of the polymeric membranes were discussed. The optimal PVA/PAA was determined as 50/50. (C) 2003 Wiley Periodicals, Inc.

引用

页码：72 / 77

页数：6

共 56 条

[1]

Aiedeh K, 1999, ARCH PHARM, V332, P103, DOI 10.1002/(SICI)1521-4184(19993)332:3<103::AID-ARDP103>3.0.CO

[2]

2-U

[3] Spectrofluorimetric determination of diclofenac in the presence of α-cyclodextrin [J].

Arancibia, JA ;

Boldrini, MA ;

Escandar, GM .

TALANTA, 2000, 52 (02) :261-268

[4] Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt [J].

Arora, P ;

Mukherjee, B .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (09) :2076-2089

[5] A comparative study of the transdermal penetration of a series of nonsteroidal antiinflammatory drugs [J].

Cordero, JA ;

Alarcon, L ;

Escribano, E ;

Obach, R ;

Domenech, J .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (04) :503-508

[6]

Crank J., 1956, The Mathematics of Diffusion

[7] Hydrogel membranes with mesh size asymmetry based on the gradient crosslinking of poly(vinyl alcohol) [J].

Dai, WS ;

Barbari, TA .

JOURNAL OF MEMBRANE SCIENCE, 1999, 156 (01) :67-79

[8] Preparation and performance of asymmetric polyetherimide membranes for isopropanol dehydration by pervaporation [J].

Feng, XS ;

Huang, RYM .

JOURNAL OF MEMBRANE SCIENCE, 1996, 109 (02) :165-172

[9]

FRIED JR, 1995, POLYM SCI TECHNOL, P459

[10] Experimental determination of the theophylline diffusion coefficient in swollen sodium-alginate membranes [J].

Grassi, M ;

Colombo, I ;

Lapasin, R .

JOURNAL OF CONTROLLED RELEASE, 2001, 76 (1-2) :93-105

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