Synthesis and Cytotoxic Activity of Some New Sulfa Drugs Containing Thiadiazole

被引：0
|
作者：
Qurban, Jihan [1 ]
Gouda, Moustafa A. [2 ,3 ]
机构：
[1] Umm Al Qum Univ, Fac Appl Sci, Dept Chem, Mecca, Saudi Arabia
[2] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt
[3] Taibah Univ, Fac Sci & Arts, Dept Chem, Medina, Saudi Arabia
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 04期
关键词：
Sulfa drugs; Thiazole; Thiadiazole; Diazonium chloride; Cytotoxic activity; ANTIOXIDANT EVALUATION; DERIVATIVES; DEPRESSANT; ANTITUMOR;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of the appropriate sulfonamide diazonium chlorides 2a-f with phenacyl thiocyanate 3 in methanol containing pyridine afforded the 2-imino-1,3,4-thiadiazols 5 a-f through the intermediates 4a-f. The cytotoxic activity of the synthesized compounds against a liver (HepG2), colon (HCT-116), breast (MCF-7), and prostate (PC3) human cancer cell lines was evaluated. The results revealed that the tested compounds displayed moderate to weak cytotoxic activity.
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页码：561 / 565
页数：5
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