The Interaction between Sex and Hyperlipidemia on Gout Risk Is Modulated by HLA-B Polymorphic Variants in Adult Taiwanese

被引：8

作者：

Hsu, Tsui-Wen ^{[1
,2
]}

Lee, Pei-Shyuan ^{[3
]}

Nfor, Oswald Ndi ^{[4
,5
]}

Lee, Chia-long ^{[6
]}

Chen, Pei-Hsin ^{[4
,5
]}

Tantoh, Disline Manli ^{[4
,5
]}

Lin, Long-Yau ^{[7
]}

Chou, Ming-Chih ^{[1
,7
]}

Lee, Yu-Chen ^{[8
]}

Liaw, Yung-Po ^{[4
,5
,9
]}

机构：

[1] Chung Shan Med Univ, Inst Med, Taichung 40201, Taiwan

[2] Cathay Gen Hosp, Superintendent Off, Taipei 106, Taiwan

[3] Cathay Gen Hosp, Neihu Clin, Dept Family Med, Taipei 106, Taiwan

[4] Chung Shan Med Univ, Dept Publ Hlth, Taichung 40201, Taiwan

[5] Chung Shan Med Univ, Inst Publ Hlth, Taichung 40201, Taiwan

[6] Cathy Gen Hosp, Dept Internal Med, Taipei 106, Taiwan

[7] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan

[8] Cathy Gen Hosp, Dept Dent, Taipei 106, Taiwan

[9] Chung Shan Med Univ Hosp, Dept Family & Community Med, Taichung 40201, Taiwan

来源：

GENES | 2019年 / 10卷 / 03期

关键词：

gout; hyperlipidemia; sex; EPIDEMIOLOGY; HYPERURICEMIA; PREVALENCE; POPULATION; NUTRITION; HEALTH;

D O I：

10.3390/genes10030246

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effects of genetic variants on the interaction between hyperlipidemia and sex have not been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National Health Insurance Research Database (NHIRD), we examined hyperlipidemia, sex, and their relationship with gout among Taiwanese adults with the human leukocyte antigen B (HLA-B) genetic variants. Hyperlipidemia was present in 1437 patients with gout. Sex and hyperlipidemia had significant associations on gout risk, with hyperlipidemia showing a relatively stronger effect. Gout was present in men, with an odds ratio (OR) of 1.945 (95% confidence interval (CI) 1.568-2.411) compared to women, and in hyperlipidemic (OR = 4.032; 95% CI: 3.581-4.540) compared to non-hyperlipidemic patients. The interaction of sex and hyperlipidemia was significant for rs2523608 GG (p = 0.0402) and rs4713518 AA (p = 0.0003) genotypes. After stratification, hyperlipidemia remained a risk factor in women (OR = 4.735, 95% CI: 3.375-6.643) and men (OR = 3.640, 95% CI: 2.916-4.544) with rs2523608 GG genotype. The odds ratio in hyperlipidemic women and men with rs4713518 AA genotype was 7.454 (95% CI 5.103-10.888) and 3.585 (95% CI 2.854-4.503), respectively. Our study indicates that hyperlipidemia-sex interactions exist for gout risk in Taiwanese adults with rs2523608 GG and rs4713518 AA genotypes.

引用

页数：9

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