Effect of penicillin G potassium salt on the physicochemical properties of SDS aqueous solution and the release of the salt in SDS/n-C5H11OH/H2O system

The effects of penicillin potassium salt (PenK) on the solubility, Krafft temperature TK, critical micelle concentration CMC of SDS micelle and the phase behavior of SDS/n-C5H11OH/H2O system were studied. The partial phase diagrams of SDS/PenK/H2O system at different temperatures were determined. The release amounts of PenK in SDS/n-C5H11OH/H2O system and the distribution coefficient of PenK between micelle and water were measured by LTV-Vis spectroscopy. The results show that in the presence of PenK, the CMC of SDS was decreased while the TK of SDS was increased and the solubility of SDS in both water and SDS/n-C5H11OH/H2O oil in water (O/W) microemulsion was decreased, but increased in water in oil (W/O) microemulsion. SDS micelles and SDS/n-C5H11OH/H2O O/W microemulsion could accelerate the release rate of PenK. The addition of SDS and water could both increase the release rate of PenK, whereas the presence of n-C5H11OH reduced the release rate of PenK. The above results were related to the electrostatic repulsion between PenK and SDS.