A top-down in-house validation based approach for the investigation of the measurement uncertainty using fractional factorial experiments

被引:48
作者
Jülicher, B
Gowik, P
Uhlig, S
机构
[1] Fed Inst Hlth Protect Consumers & Vet Med, EU Reference Lab Residues Vet Drugs, D-14191 Berlin, Germany
[2] Free Univ Berlin, Inst Stat & Econometr, D-14195 Berlin, Germany
关键词
D O I
10.1039/a807077f
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The recently presented in-house validation concept developed on the basis of a variance component model is extended and optimised by basing it on a fractional factorial sampling scheme. The presented approach relies on a comprehensive mathematical model to assess simultaneously the in-house reproducibility and its components in addition to uncertainty-related performance characteristics like power functions and critical concentrations. The influence of individual factors and the corresponding uncertainties can be determined separately in a single experiment with optimum utilization of the generated data, in this way achieving a favourable ratio between costs and result.
引用
收藏
页码:537 / 545
页数:9
相关论文
共 9 条
[1]  
[Anonymous], 1995, ANALYST, V120, P2303
[2]  
ELLISON S, 1997, ANAL CHEM A, V607
[3]   Using validation data for ISO measurement uncertainty estimation - Part 1. Principles of an approach using cause and effect analysis [J].
Ellison, SLR ;
Barwick, VJ .
ANALYST, 1998, 123 (06) :1387-1392
[4]  
*EURACHEM SECR, 1995, QUANT UNC AN MEAS
[5]   Multi-residue method for non-steroidal anti-inflammatory drugs in plasma using high-performance liquid chromatography photodiode-array detection -: Method description and comprehensive in-house validation [J].
Gowik, P ;
Jülicher, B ;
Uhlig, S .
JOURNAL OF CHROMATOGRAPHY B, 1998, 716 (1-2) :221-232
[6]  
Horwitz W, 1998, J AOAC INT, V81, P785
[7]  
International Organization for Standardization, 1995, GUID EXPR UNC MEAS I
[8]   Assessment of detection methods in trace analysis by means of a statistically based in-house validation concept [J].
Jülicher, B ;
Gowik, P ;
Uhlig, S .
ANALYST, 1998, 123 (02) :173-179
[9]   Uncertainty of sampling in chemical analysis [J].
Thompson, M .
ACCREDITATION AND QUALITY ASSURANCE, 1998, 3 (03) :117-121