Akinetic Mutism Caused by HIV-associated Progressive Multifocal Leukoencephalopathy was Successfully Treated with Mefloquine: A Serial Multimodal MRI Study

被引：14

作者：

Naito, Kasane ^{[1
,2
]}

Ueno, Hiroki ^{[1
]}

Sekine, Mayu ^{[1
,3
]}

Kanemitsu, Munekazu ^{[1
]}

Ohshita, Tomohiko ^{[1
,4
]}

Nakamura, Takeshi ^{[1
]}

Yamawaki, Takemori ^{[1
]}

Matsumoto, Masayasu ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Clin Neurosci & Therapeut, Hiroshima 730, Japan

[2] Hiroshima City Hosp, Dept Neurol, Hiroshima, Japan

[3] Tokyo Saiseikai Cent Hosp, Dept Neurol, Tokyo, Japan

[4] Suiseikai Kajikawa Hosp, Dept Neurol, Hiroshima, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 02期

关键词：

progressive multifocal leukoencephalopathy (PML); human immunodeficiency virus infection (HIV); highly active anti-retroviral therapy (HAART); mefloquine; proton magnetic resonance spectroscopy (H-1-MRS); apparent diffusion coefficient (ADC); ACTIVE ANTIRETROVIRAL THERAPY; SURVIVAL; SPECTROSCOPY;

D O I：

10.2169/internalmedicine.51.6253

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of a patient with highly active anti-retroviral therapy-resistant human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML). The patient showed an improvement in imaging findings and clinical symptoms after mefloquine was introduced as an additional treatment. Serial assessment of white matter lesions was conducted by proton magnetic resonance spectroscopy (H-1-MRS) and diffusion-weighted imaging (DWI). As the clinical symptoms improved, the N-acetylaspartate/creatine ratio increased, the choline/creatine ratio decreased, and the elevated ADC value decreased. These concomitant changes suggested that H-1-MRS and DWI were useful for the assessment of the therapeutic effect on PML.

引用

页码：205 / 209

页数：5

共 26 条

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