SWI/SNF Chromatin Remodeling Complex: A New Cofactor in Reprogramming

被引：11

作者：

He, Ling ^{[1
]}

Liu, Huan ^{[1
]}

Tang, Liling ^{[1
]}

机构：

[1] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Coll Bioengn, Chongqing 400044, Peoples R China

来源：

STEM CELL REVIEWS AND REPORTS | 2012年 / 8卷 / 01期

关键词：

SWI/SNF; Reprogramming; Pluripotent factors; Embryonic stem cells; Induced pluripotent stem cells; PLURIPOTENT STEM-CELLS; FUNCTIONAL DIFFERENCES; REGULATE PLURIPOTENCY; SOMATIC-CELLS; FIBROBLASTS; NANOG; EXPRESSION; REQUIRES; MECHANISMS; INDUCTION;

D O I：

10.1007/s12015-011-9285-z

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Induced pluripotent stem (iPS) cells can be derived from somatic cells. Four key factors are required in this process including Oct4, Sox2, Klf4 and c-Myc. Ectopic expression of these four factors in somatic cells leads to reprogramming. Recent studies show that the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex plays critical roles in reprogramming of somatic cells and maintaining the pluripotency of stem cells. The possible mechanism is that SWI/SNF enhances the binding activity of reprogramming factors to pluripotent gene promoters and thus increases the reprogramming efficiency. Here, we review these recent advances and discuss how SWI/SNF plays a role in reprogramming. Understanding this mechanism will be helpful to find out the detail of reprogramming, which may provide a new therapy in medical science by generating patient-specific pluripotent stem cells.

引用

页码：128 / 136

页数：9

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