Mitochondrial dynamics and apoptosis

被引：1054

作者：

Suen, Der-Fen ^{[1
]}

Norris, Kristi L. ^{[1
]}

Youle, Richard J. ^{[1
]}

机构：

[1] NINDS, Biochem Sect, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 12期

关键词：

Bax; Bcl-2; Drp1; Mfn2; OPA1; fission;

D O I：

10.1101/gad.1658508

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondrial fission and fusion also actively participate in apoptosis induction. This review will cover the recent advances and presents competing models on how the mitochondrial fission and fusion machinery may intersect apoptosis pathways.

引用

页码：1577 / 1590

页数：14

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