MEMS: Enabled Drug Delivery Systems

被引:55
作者
Cobo, Angelica [1 ]
Sheybani, Roya [1 ]
Meng, Ellis [1 ,2 ]
机构
[1] Univ So Calif, Viterbi Sch Engn, Dept Biomed Engn, Los Angeles, CA 90089 USA
[2] Univ So Calif, Viterbi Sch Engn, Dept Elect Engn, Los Angeles, CA 90089 USA
关键词
drug delivery; microelectromechanical systems; micropumps; CONTROLLED-RELEASE; OSMOTIC PUMP; FLOW SENSORS; MICROPUMP; DEVICES; MICRONEEDLE; INSULIN; MICROVALVES; MEDICINE; IMPLANTS;
D O I
10.1002/adhm.201400772
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Drug delivery systems play a crucial role in the treatment and management of medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. This Review presents the use of MEMS technologies to produce drug delivery devices detailing the delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.
引用
收藏
页码:969 / 982
页数:14
相关论文
共 114 条
[1]  
Abhari F, 2012, INT J ELECTROCHEM SC, V7, P9765
[2]   Current micropump technologies and their biomedical applications [J].
Amirouche, Farid ;
Zhou, Yu ;
Johnson, Tom .
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS, 2009, 15 (05) :647-666
[3]  
Andersen S.O., 2012, PROTECTING OZONE LAY
[4]  
[Anonymous], DRAFT GUID IN PRESS
[5]  
[Anonymous], 2014, ALLERGAN ACQUIRES LI
[6]   Microvalves and Micropumps for BioMEMS [J].
Au, Anthony K. ;
Lai, Hoyin ;
Utela, Ben R. ;
Folch, Albert .
MICROMACHINES, 2011, 2 (02) :179-220
[7]   CONTROL OF BLOOD-GLUCOSE IN EXPERIMENTAL DIABETES BY MEANS OF A TOTALLY IMPLANTABLE INSULIN INFUSION DEVICE [J].
BLACKSHEAR, PJ ;
ROHDE, TD ;
GROTTING, JC ;
DORMAN, FD ;
PERKINS, PR ;
VARCO, RL ;
BUCHWALD, H .
DIABETES, 1979, 28 (07) :634-639
[8]   A closed-loop controlled electrochemically actuated micro-dosing system [J].
Böhm, S ;
Timmer, B ;
Olthuis, W ;
Bergveld, P .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2000, 10 (04) :498-504
[9]   Intraocular implants for extended drug delivery: Therapeutic applications [J].
Bourges, J. L. ;
Bloquel, C. ;
Thomas, A. ;
Froussart, F. ;
Bochot, A. ;
Azan, F. ;
Gurny, R. ;
BenEzra, D. ;
Behar-Cohen, F. .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (11) :1182-1202
[10]   Design and simulation of an electrostatic micropump for drug-delivery applications [J].
Bourouina, T ;
Bosseboeuf, A ;
Grandchamp, JP .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 1997, 7 (03) :186-188