HUMAN CANCER-ASSOCIATED FIBROBLAST SUBSETS CAN PREDICT IMMUNE CHECKPOINT RESPONSE IN HEAD AND NECK CANCER PATIENTS

被引:0
作者
Graves, Diana [1 ]
Obradovic, Aleksandar [2 ]
Korrer, Michael [3 ]
Wang, Yu [3 ]
Roy, Sohini [3 ]
Xu, Yaomin [3 ]
Luginbuhl, Adam [4 ]
Curry, Joseph [4 ]
Gibson, Michael [3 ]
Hurley, Paula [3 ]
Uppaluri, Ravindra [5 ]
Drake, Charles
Califano, Andrea
Kim, Young [3 ]
机构
[1] Vanderbilt Univ, Antioch, TN USA
[2] Columbia Univ, New York, NY 10027 USA
[3] Vanderbilt Univ, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA
[4] Thomas Jefferson Univ, Philadelphia, PA 19107 USA
[5] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
SQUAMOUS-CELL CARCINOMA; RECURRENT;
D O I
10.1136/jitc-2021-SITC2021.903
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
903
引用
收藏
页码:A947 / A947
页数:1
相关论文
共 6 条
  • [1] Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy
    Dominguez, Claudia X.
    Mueller, Soren
    Keerthivasan, Shilpa
    Koeppen, Hartmut
    Hung, Jeffrey
    Gierke, Sarah
    Breart, Beatrice
    Foreman, Oded
    Bainbridge, Travis W.
    Castiglioni, Alessandra
    Senbabaoglu, Yasin
    Modrusan, Zora
    Liang, Yuxin
    Junttila, Melissa R.
    Klijn, Christiaan
    Bourgon, Richard
    Turley, Shannon J.
    [J]. CANCER DISCOVERY, 2020, 10 (02) : 232 - 253
  • [2] Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    Feig, Christine
    Jones, James O.
    Kraman, Matthew
    Wells, Richard J. B.
    Deonarine, Andrew
    Chan, Derek S.
    Connell, Claire M.
    Roberts, Edward W.
    Zhao, Qi
    Caballero, Otavia L.
    Teichmann, Sarah A.
    Janowitz, Tobias
    Jodrell, Duncan I.
    Tuveson, David A.
    Fearon, Douglas T.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (50) : 20212 - 20217
  • [3] Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
    Ferris, R. L.
    Blumenschein, G., Jr.
    Fayette, J.
    Guigay, J.
    Colevas, A. D.
    Licitra, L.
    Harrington, K.
    Kasper, S.
    Vokes, E. E.
    Even, C.
    Worden, F.
    Saba, N. F.
    Iglesias Docampo, L. C.
    Haddad, R.
    Rordorf, T.
    Kiyota, N.
    Tahara, M.
    Monga, M.
    Lynch, M.
    Geese, W. J.
    Kopit, J.
    Shaw, J. W.
    Gillison, M. L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (19) : 1856 - 1867
  • [4] Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer
    Kieffer, Yann
    Hocine, Hocine R.
    Gentric, Geraldine
    Pelon, Floriane
    Bernard, Charles
    Bourachot, Brigitte
    Lameiras, Sonia
    Albergante, Luca
    Bonneau, Claire
    Guyard, Alice
    Tarte, Karin
    Zinovyev, Andrei
    Baulande, Sylvain
    Zalcman, Gerard
    Vincent-Salomon, Anne
    Mechta-Grigoriou, Fatima
    [J]. CANCER DISCOVERY, 2020, 10 (09) : 1330 - 1351
  • [5] Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages
    Obradovic, Aleksandar
    Chowdhury, Nivedita
    Haake, Scott M.
    Ager, Casey
    Wang, Vinson
    Vlahos, Lukas
    Guo, Xinzheng, V
    Aggen, David H.
    Rathmell, W. Kimryn
    Jonasch, Eric
    Johnson, Joyce E.
    Roth, Marc
    Beckermann, Kathryn E.
    Rini, Brian, I
    McKiernan, James
    Califano, Andrea
    Drake, Charles G.
    [J]. CELL, 2021, 184 (11) : 2988 - +
  • [6] Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial
    Seiwert, Tanguy Y.
    Burtness, Barbara
    Mehra, Ranee
    Weiss, Jared
    Berger, Raanan
    Eder, Joseph Paul
    Heath, Karl
    McClanahan, Terrill
    Lunceford, Jared
    Gause, Christine
    Cheng, Jonathan D.
    Chow, Laura Q.
    [J]. LANCET ONCOLOGY, 2016, 17 (07) : 956 - 965