Direct dilithiation of N-aryl heterocycles for the construction of condensed N-heterocycles

被引：2

作者：

Zhang, Hong ^{[1
]}

Di, Shu-Sheng ^{[1
]}

Huang, Xiao-Bo ^{[1
]}

Zhou, Yun-Bing ^{[1
]}

Liu, Miao-Chang ^{[1
]}

Wu, Hua-Yue ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 10期

基金：

中国国家自然科学基金;

关键词：

STRUCTURAL-CHARACTERIZATION; DERIVATIVES; CHEMISTRY; DIANIONS;

D O I：

10.1039/d1qo01896e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 1,4-dilithio intermediate can be prepared from N-heterocycles by n-BuLi-promoted direct C-H dilithiation. The subsequent trapping of the 1,4-dilithio intermediate with acyl chlorides affords condensed N-heterocycles in high yields in a one-pot fashion. This protocol features a broad substrate scope, good efficiency, and high atom economy. The control experiments support the presence of a 1,4-dilithio intermediate.

引用

页码：2659 / 2663

页数：5

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