Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea

被引：6

作者：

Liu, Lanying ^{[1
]}

Guan, Fuqin ^{[2
]}

Chen, Yu ^{[2
]}

Wang, Fan ^{[2
,3
]}

Chen, Pengxu ^{[2
,3
]}

Yin, Min ^{[2
]}

Wang, Bi ^{[2
]}

Li, Linwei ^{[2
]}

Wang, Qizhi ^{[2
]}

Gu, Yonghua ^{[2
]}

Feng, Xu ^{[2
,3
]}

机构：

[1] Ningxia Acad Agr & Forestry Sci, Natl Wolfberry Engn Technol Res Ctr, Yinchuan 750002, Ningxia, Peoples R China

[2] Jiangsu Prov & Chinese Acad Sci, Jiangsu Prov Engn Res Ctr Ecocultivat & High Valu, Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing 210014, Peoples R China

[3] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 18期

关键词：

Atractylodes lancea; sesquiterpenoid glycosides; secoatractylohexone A; network pharmacology; POLYACETYLENE GLYCOSIDES;

D O I：

10.3390/molecules27185753

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-beta-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3-7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes.

引用

页数：11

共 29 条

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