Effect of lycopine on the resistance of rat liver microsomes to in vitro induced LPO

被引：5
作者：
Kravchenko, LV [1 ]
Morozov, SV [1 ]
Tutel'yan, VA [1 ]
机构：
[1] Russian Acad Med Sci, Inst Nutr, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 01期
关键词：
lycopine; microsomes; lipid peroxidation; benz[a]pyrene hydroxylation; UDP-glucuronosyl transferase;
D O I：
10.1023/A:1026097015125
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lycopine in concentrations of 0.5-50 muM suppressed LPO in microsomes induced by NADPH-Fe2+ and by ascorbic acid-Fe2+. Lycopine in a concentration of 20 muM completely prevented the decrease in the rate of benz[a]pyrene hydroxylation and activation of p-nitrophenyl-UDP-glucuronosyl transferase caused by LPO induction in microsomes.
引用
收藏
页码：66 / 69
页数：4
相关论文
共 13 条
  • [1] Archakov A.I., 1990, CYTOCHROME P450 ACTI
  • [2] Burchell B, 1981, Methods Enzymol, V77, P169
  • [3] Singlet oxygen quenching by dietary carotenoids in a model membrane environment
    Cantrell, A
    McGarvey, DJ
    Truscott, TG
    Rancan, F
    Böhm, F
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 412 (01) : 47 - 54
  • [4] MODIFIED METHOD FOR ASSAY OF BENZO[A]PYRENE HYDROXYLASE
    DEHNEN, W
    TOMINGAS, R
    ROOS, J
    [J]. ANALYTICAL BIOCHEMISTRY, 1973, 53 (02) : 373 - 383
  • [5] Dugas TR, 1998, J LIPID RES, V39, P999
  • [6] The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage
    Hadley, CW
    Clinton, SK
    Schwartz, SJ
    [J]. JOURNAL OF NUTRITION, 2003, 133 (03) : 727 - 732
  • [7] No significant effects of lutein, lycopene or β-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects
    Hininger, IA
    Meyer-Wenger, A
    Moser, U
    Wright, A
    Southon, S
    Thurnham, D
    Chopra, M
    Van den Berg, H
    Olmedilla, B
    Favier, AE
    Roussel, AM
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2001, 20 (03) : 232 - 238
  • [8] Klebanov GI, 1998, BIOL MEMBRANY, V15, P227
  • [9] KRAVCHENKO LV, 2003, BYUL EKSPER BIOL, V135, P414
  • [10] Antioxidant activities of astaxanthin and related carotenoids
    Naguib, YMA
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (04) : 1150 - 1154
12