The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

被引：71
作者：
Yu, Dawei [1 ,2 ]
Feng, Jiayao [1 ,2 ]
You, Huimin [1 ,2 ]
Zhou, Shipeng [1 ,2 ]
Bai, Yan [3 ]
He, Jincan [3 ]
Cao, Hua [4 ]
Che, Qishi [5 ]
Guo, Jiao [2 ]
Su, Zhengquan [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Guangdong Engn Res Ctr Nat Prod & New Drugs, Guangdong Prov Univ, Engn Technol Res Ctr Nat Prod & Drugs, Guangzhou 510006, Peoples R China
[2] Guangdong Pharmaceut Univ, Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangdong TCM Key Lab Metab Dis, Minist Educ,Key Lab Glucolipid Metab Disorder, Guangzhou 510006, Peoples R China
[3] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510310, Peoples R China
[4] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
[5] Guangzhou Rainhome Pharm & Tech Co Ltd, Guangzhou 510663, Peoples R China
来源：
MARINE DRUGS | 2022年 / 20卷 / 01期
基金：
中国国家自然科学基金;
关键词：
chitosan oligosaccharide; derivatives; antimicrobial; antitumor; NF-KAPPA-B; ANTIMICROBIAL PROPERTIES; BIOLOGICAL-ACTIVITIES; NANOPARTICLES; CANCER; LACTATE; CHARGE; CHITOOLIGOSACCHARIDES; EMULSIONS; THERAPY;
D O I：
10.3390/md20010069
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chitosan obtained from abundant marine resources has been proven to have a variety of biological activities. However, due to its poor water solubility, chitosan application is limited, and the degradation products of chitosan oligosaccharides are better than chitosan regarding performance. Chitosan oligosaccharides have two kinds of active groups, amino and hydroxyl groups, which can form a variety of derivatives, and the properties of these derivatives can be further improved. In this review, the key structures of chitosan oligosaccharides and recent studies on chitosan oligosaccharide derivatives, including their synthesis methods, are described. Finally, the antimicrobial and antitumor applications of chitosan oligosaccharides and their derivatives are discussed.
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页数：19
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