The Effect of Non-invasive Spinal Cord Stimulation on Anorectal Function in Individuals With Spinal Cord Injury: A Case Series

被引：9

作者：

Kreydin, Evgeniy ^{[1
,2
,3
]}

Zhong, Hui ^{[2
,4
]}

Lavrov, Igor ^{[5
,6
]}

Edgerton, V. Reggie ^{[4
,7
,8
,9
]}

Gad, Parag ^{[2
,3
,4
]}

机构：

[1] Univ Southern Calif, Inst Urol, Keck Sch Med, Los Angeles, CA 90007 USA

[2] Rancho Res Inst, Rancho Los Amigos Natl Rehabil Ctr, Downey, CA 90242 USA

[3] SpineX Inc, Los Angeles, CA 91324 USA

[4] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90032 USA

[5] Mayo Clin, Dept Neurol, Dept Biomed Engn, Rochester, NY USA

[6] Kazan Fed Univ, Inst Fundamental Med & Biol, Kazan, Russia

[7] Univ Calif Los Angeles, Dept Neurosurg, Los Angeles, CA USA

[8] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA USA

[9] Univ Autonoma Barcelona, Inst Univ Adscrit, Hosp Neurorehabil, Inst Guttmann, Barcelona, Spain

来源：

FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷

基金：

美国国家科学基金会;

关键词：

non-invasive spinal cord stimulation; spinal cord injury; stroke; multiple sclerosis; neurogenic bladder; overactive bladder urodynamics; NEUROGENIC BOWEL DYSFUNCTION; MAGNETIC STIMULATION; ELECTRICAL-STIMULATION; RECOVERY; LATENCY;

D O I：

10.3389/fnins.2022.816106

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cord injury (SCI) is a devastating condition that impacts multiple organ systems. Neurogenic bowel dysfunction (NBD) frequently occurs after a SCI leading to reduced sensation of bowel fullness and bowel movement often leading to constipation or fecal incontinence. Spinal Neuromodulation has been proven to be a successful modality to improve sensorimotor and autonomic function in patients with spinal cord injuries. The pilot data presented here represents the first demonstration of using spinal neuromodulation to activate the anorectal regions of patients with spinal cord injuries and the acute and chronic effects of stimulation. We observed that spinal stimulation induces contractions as well as changes in sensation and pressure profiles along the length of the anorectal region. In addition, we present a case report of a patient with a SCI and the beneficial effect of spinal neuromodulation on the patient's bowel program.

引用

页数：7

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