Inhibitors of Angiogenesis

被引：3

作者：

Buening, H. ^{[1
]}

Hacker, U. T. ^{[2
]}

机构：

[1] Hannover Med Sch, Inst Expt Hematol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] Univ Klinikum Leipzig, Univ Krebszentrum UCCL, Liebigstr 20, D-04103 Leipzig, Germany

来源：

PROTEIN TARGETING COMPOUNDS: PREDICTION, SELECTION AND ACTIVITY OF SPECIFIC INHIBITORS | 2016年 / 917卷

关键词：

Angiogenesis; VEGF; Vascular maturation; Antibodies; Gene therapy; METASTATIC COLORECTAL-CANCER; ENDOTHELIAL GROWTH-FACTOR; RANDOMIZED PHASE-III; RENAL-CELL CARCINOMA; ANTIANGIOGENIC GENE-THERAPY; HERPES-SIMPLEX-VIRUS; ANTI-VEGF AGENTS; DOUBLE-BLIND; TUMOR-GROWTH; OCULAR NEOVASCULARIZATION;

D O I：

10.1007/978-3-319-32805-8_12

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Angiogenesis plays a pivotal role in malignant, ischemic, inflammatory, infectious and immune disorders. The increasing molecular understanding of angiogenic processes fostered the development of strategies to induce or inhibit angiogenesis for therapeutic purposes. Here, we focus on anti-angiogenic therapies, which represent a standard of care in the treatment of different cancer types and in neovascular age-related macular degeneration. Specifically, strategies related to the blockade of angiogenic proteins and receptors will be outlined covering both preclinical and clinical aspects. Finally, examples of gene therapy based anti-angiogenic approaches are presented.

引用

页码：261 / 285

页数：25

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