Strong ion reserve: a viewpoint on acid base equilibria and buffering

被引：6
作者：
Agrafiotis, Michalis [1 ]
机构：
[1] Georgios Papanikolaou Gen Hosp Thessaloniki, Dept Intens Care Med 2, Exochi 57010, Greece
来源：
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY | 2011年 / 111卷 / 08期
关键词：
Strong ion difference; Stewart's model; Quantitative acid base physiology; IONIZED CALCIUM; CARBON-DIOXIDE; SERUM-ALBUMIN; BINDING; OXYGEN; PH; PARAMETERS; CHEMISTRY; HYDROGEN; INVIVO;
D O I：
10.1007/s00421-010-1803-1
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Evidence suggests that strong ions can exist reversibly bound to proteins in a pH-dependent manner and that they can be recruited into the biological solution, modulating its strong ion difference in a process that opposes the acid base disturbances imposed on the system. These recruitable strong ions represent the solution's "strong ions". The physiological role of these protein-bound strong ion reserve in the buffering of acid base disorders is discussed.
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页码：1951 / 1954
页数：4
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