RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization

被引：31

作者：

Anwar, Naveed ^{[1
]}

Rix, Anne ^{[2
]}

Lederle, Wiltrud ^{[2
]}

Kuehne, Alexander J. C. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, DWI Leibniz Inst Interact Mat, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Dept Expt Mol Imaging, Fac Med, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 45期

关键词：

CLICK CHEMISTRY; NANOPARTICLES; DOTS; SIZE; NANOSPHERES; DENSITY; DEVICES;

D O I：

10.1039/c4cc10092a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we present a facile one-step Sonogashira dispersion polymerization affording monodisperse conjugated polymer particles bearing accessible acetylene moieties on the surface. These acetylene groups are easily functionalized with biological recognition motifs using thiolyne click chemistry. The resulting functional particles are applied as fluorescent probes for imaging of activated endothelial cells, which take up the particles via receptor mediated endocytosis.

引用

页码：9358 / 9361

页数：4

共 35 条

[1] Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol-ene/thiol-yne photoreactions [J].

Aimetti, Alex A. ;

Feaver, Kristen R. ;

Anseth, Kristi S. .

CHEMICAL COMMUNICATIONS, 2010, 46 (31) :5781-5783

[2] Light-Switchable and Monodisperse Conjugated Polymer Particles [J].

Anwar, Naveed ;

Willms, Thomas ;

Grimme, Benjamin ;

Kuehne, Alexander J. C. .

ACS MACRO LETTERS, 2013, 2 (09) :766-769

[3] Fluorescent Conjugated Polymer Nanoparticles by Polymerization in Miniemulsion [J].

Baier, Moritz C. ;

Huber, Johannes ;

Mecking, Stefan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (40) :14267-14273

[4] Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[5] The sonogashira reaction:: A booming methodology in synthetic organic chemistry [J].

Chinchilla, Rafael ;

Najera, Carmen .

CHEMICAL REVIEWS, 2007, 107 (03) :874-922

[6] The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility [J].

Dash, Biraja C. ;

Rethore, Gildas ;

Monaghan, Michael ;

Fitzgerald, Kathleen ;

Gallagher, William ;

Pandit, Abhay .

BIOMATERIALS, 2010, 31 (32) :8188-8197

[7] Preparation and Biofunctionalization of Multicolor Conjugated Polymer Nanoparticles for Imaging and Detection of Tumor Cells [J].

Feng, Liheng ;

Liu, Libing ;

Lv, Fengting ;

Bazan, Guillermo C. ;

Wang, Shu .

ADVANCED MATERIALS, 2014, 26 (23) :3926-3930

[8] Mechanism of Cellular Uptake of Highly Fluorescent Conjugated Polymer Nanoparticles [J].

Fernando, Lawrence P. ;

Kandel, Prakash K. ;

Yu, Jiangbo ;

McNeill, Jason ;

Ackroyd, P. Christine ;

Christensen, Kenneth A. .

BIOMACROMOLECULES, 2010, 11 (10) :2675-2682

[9] Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis [J].

Hanahan, D ;

Folkman, J .

CELL, 1996, 86 (03) :353-364

[10]

Heeger AJ, 2001, ANGEW CHEM INT EDIT, V40, P2591, DOI 10.1002/1521-3773(20010716)40:14<2591::AID-ANIE2591>3.0.CO

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