RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization

被引：31

作者：

Anwar, Naveed ^{[1
]}

Rix, Anne ^{[2
]}

Lederle, Wiltrud ^{[2
]}

Kuehne, Alexander J. C. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, DWI Leibniz Inst Interact Mat, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Dept Expt Mol Imaging, Fac Med, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 45期

关键词：

CLICK CHEMISTRY; NANOPARTICLES; DOTS; SIZE; NANOSPHERES; DENSITY; DEVICES;

D O I：

10.1039/c4cc10092a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we present a facile one-step Sonogashira dispersion polymerization affording monodisperse conjugated polymer particles bearing accessible acetylene moieties on the surface. These acetylene groups are easily functionalized with biological recognition motifs using thiolyne click chemistry. The resulting functional particles are applied as fluorescent probes for imaging of activated endothelial cells, which take up the particles via receptor mediated endocytosis.

引用

页码：9358 / 9361

页数：4

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