Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation

被引：5

作者：

Cetinkaya, Feyza Izci ^{[1
]}

Mumcu, Necati ^{[1
]}

Unuvar, Gamze Kalin ^{[1
]}

Kilic, Aysegul Ulu ^{[1
]}

Kaynar, Leylagul ^{[2
]}

机构：

[1] Erciyes Univ, Dept Infect Dis, Fac Med, Kayseri, Turkey

[2] Erciyes Univ, Dept Hematol, Fac Med, Kayseri, Turkey

来源：

NORTHERN CLINICS OF ISTANBUL | 2022年 / 9卷 / 03期

关键词：

Allogeneic stem cell transplantation; encephalitis; toxoplasmosis; CEREBRAL TOXOPLASMOSIS; INFECTION; GONDII; RECIPIENT;

D O I：

10.14744/nci.2020.66049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cerebral toxoplasmosis is a rare but often life-threatening infection after hematopoietic stem cell transplantation (HSCT). In such cases, early diagnosis and initiation of treatment are vital. We describe a case of cerebral toxoplasmosis in a patient who underwent HSCT for acute myeloid leukemia. Infection was diagnosed with polymerase chain reaction (PCR) test of cerebrospinal fluid and cranial magnetic resonance imaging scan. The patient treated with trimethoprim-sulfamethoxazole and clindamycin combination. However, she died from nosocomial infection after 15 days of treatment. This life-threatening infection should be considered in a patient who is post-HSCT present with neurologic symptoms and brain lesions. PCR is an important and rapid diagnostic tool for toxoplasmosis. Cranial imaging scan and PCR should be used together to diagnosed.

引用

页码：282 / 285

页数：4

共 15 条

[1] Cerebral toxoplasmosis in an allogeneic peripheral stem cell transplant recipient: case report and review of literature
Cibickova, L.
Horacek, J.
Prasil, P.
Slovacek, L.
Kohout, A.
Cerovsky, V.
Hobza, V.
[J]. TRANSPLANT INFECTIOUS DISEASE, 2007, 9 (04) : 332 - 335
[2] Diagnosis of central nervous system complications in HIV-infected patients: Cerebrospinal fluid analysis by the polymerase chain reaction
Cinque, P
Scarpellini, P
Vago, L
Linde, A
Lazzarin, A
[J]. AIDS, 1997, 11 (01) : 1 - 17
[3] Analysis of cerebral toxoplasmosis in a series of 170 allogeneic hematopoietic stem cell transplant patients
Hakko, E.
Ozkan, H. A.
Karaman, K.
Gulbas, Z.
[J]. TRANSPLANT INFECTIOUS DISEASE, 2013, 15 (06) : 575 - 580
[4] Khalaf AM, 2017, AM J CASE REP, V18, DOI 10.12659/AJCR.899687
[5] Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation
Martino, R
Bretagne, S
Einsele, H
Maertens, J
Ullmann, AJ
Parody, R
Schumacher, U
Pautas, C
Theunissen, K
Schindel, C
Muñoz, C
Margall, N
Cordonnier, C
[J]. CLINICAL INFECTIOUS DISEASES, 2005, 40 (01) : 67 - 78
[6] Opportunistic CNS infection after bone marrow transplantation
Maschke, M
Dietrich, U
Prumbaum, M
Kastrup, O
Turowski, B
Schaefer, UW
Diener, HC
[J]. BONE MARROW TRANSPLANTATION, 1999, 23 (11) : 1167 - 1176
[7] Myeloablative Conditioning Predisposes Patients for Toxoplasma gondii Reactivation after Allogeneic Stem Cell Transplantation
Meers, Stef
Lagrou, Katrien
Theunissen, Koen
Dierickx, Daan
Delforge, Michel
Devos, Timothy
Janssens, Ann
Meersseman, Wouter
Verhoef, Gregor
Van Eldere, Johan
Maertens, Johan
[J]. CLINICAL INFECTIOUS DISEASES, 2010, 50 (08) : 1127 - 1134
[8] Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two case reports and review of the literature
Miyagi, T.
Itonaga, H.
Aosai, F.
Taguchi, J.
Norose, K.
Mochizuki, K.
Fujii, H.
Furumoto, A.
Ohama, M.
Karimata, K.
Yamanoha, A.
Taniguchi, H.
Sato, S.
Taira, N.
Moriuchi, Y.
Fukushima, T.
Masuzaki, H.
Miyazaki, Y.
[J]. TRANSPLANT INFECTIOUS DISEASE, 2015, 17 (04) : 593 - 598
[9] Toxoplasmosis
Montoya, JG
Liesenfeld, O
[J]. LANCET, 2004, 363 (9425) : 1965 - 1976
[10] Toxoplasmosis in allo-SCT patients: risk factors and outcomes at a transplantation center with a low incidence
Mulanovich, V. E.
Ahmed, S. I.
Ozturk, T.
Khokhar, F. A.
Kontoyiannis, D. P.
de Lima, M.
[J]. BONE MARROW TRANSPLANTATION, 2011, 46 (02) : 273 - 277

← 1 2 →