The P2X7 Receptor as Regulator of T Cell Development and Function

被引：37

作者：

Grassi, Fabio ^{[1
]}

机构：

[1] Univ Svizzera Italiana, Inst Res Biomed, Fac Biomed Sci, Bellinzona, Switzerland

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

瑞士国家科学基金会;

关键词：

T cell; extracellular ATP (eATP); T cell effector function; mucosal immunology; T cell development; PURINERGIC RECEPTOR; EXTRACELLULAR ATP; ADP-RIBOSYLATION; DENDRITIC CELLS; L-SELECTIN; ACTIVATION; RELEASE; CD62L; LYMPHOCYTES; GENERATION;

D O I：

10.3389/fimmu.2020.01179

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unique structural features characterize the P2X7 receptor with respect to other P2X family members. Dual gating by eATP and regulated expression of P2X7 can imprint distinct outcomes to the T cell depending on the metabolic fitness and/or developmental stage. In the thymus, signaling by P2X7 contributes to gamma delta T cell lineage choice. In secondary lymphoid organs, P2X7 stimulation promotes Th1/Th17 polarization of CD4(+)naive cells, Tregs conversion to Th17 cells and cell death of Tfh cells that are not stimulated by cognate antigen. Moreover, P2X7 stimulation in eATP rich microenvironments, such as damaged and/or inflamed tissues as well as tumors, induces cell death of various T cell effector subsets.

引用

页数：6

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