Possible application of circulating free tumor DNA in non-small cell lung cancer patients

被引：12
作者：
Karachaliou, Niki [1 ,2 ]
Sosa, Aaron E. [1 ]
Angel Molina, Miguel [3 ]
Centelles Ruiz, Margarita [4 ]
Rosell, Rafael [1 ,2 ,5 ,6 ]
机构：
[1] Univ Hosp Sagrat Cor, Inst Oncol Dr Rosell IOR, Barcelona, Spain
[2] Quiron Dexeus Univ Inst, Coyote Res Grp, Pangaea Oncol, Lab Mol Biol, Barcelona, Spain
[3] Quiron Dexeus Univ Inst, Pangaea Oncol, Lab Mol Biol, Barcelona, Spain
[4] Univ Hosp Sagrat Cor, Med Oncol Dept, Barcelona, Spain
[5] Inst Invest Ciencies Germans Trias & Pujol, Badalona, Spain
[6] Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Badalona, Spain
来源：
JOURNAL OF THORACIC DISEASE | 2017年 / 9卷
关键词：
Lung cancer; cell-free DNA (cfDNA); epidermal growth factor receptor (EGFR); liquid biopsies; RESPONSE EVALUATION CRITERIA; KRAS MUTATIONS; OPEN-LABEL; INTERCALATED ERLOTINIB; 1ST-LINE ERLOTINIB; LIQUID BIOPSIES; EGFR MUTATIONS; ADVANCED NSCLC; PHASE-III; SERUM DNA;
D O I：
10.21037/jtd.2017.09.59
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Liquid biopsies have been heralded as a game changer in cancer management. Blood tests offer a minimally invasive, safe and sensitive complementary (or even alternative) approach for tissue biopsies. With lung cancer being the second most commonly diagnosed cancer and the leading cause of cancer deaths worldwide, due to the limitations of tissue sampling, liquid biopsies must urgently materialize in the clinic. In this short review, we will present the current applications of cell-free DNA (cfDNA) in lung cancer management, emphasizing on our own experience and previous work. We will also shortly comment on the challenges and need for a coordinated collaboration combining disciplines and sectors (from academia to health economies) in order to accelerate liquid biopsy development in lung cancer and other cancers.
引用
收藏
页码：S1364 / S1372
页数：9
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