Heparin-Induced Thrombocytopenia: A Review for Cardiac Anesthesiologists and Intensivists

被引：7

作者：

Ivascu, Natalia S. ^{[1
]}

Fitzgerald, Meghann ^{[1
]}

Ghadimi, Kamrouz ^{[2
]}

Patel, Prakash ^{[3
]}

Evans, Adam S. ^{[4
]}

Goeddel, Lee A. ^{[5
]}

Shaefi, Shaz ^{[6
]}

Klick, John ^{[7
]}

Johnson, Angela ^{[7
]}

Raiten, Jesse ^{[3
]}

Horak, Jiri ^{[3
]}

Gutsche, Jacob ^{[3
]}

机构：

[1] Weill Cornell Med, Dept Anesthesiol, New York, NY USA

[2] Duke Univ, Dept Anesthesiol, Durham, NC USA

[3] Univ Penn, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 USA

[4] Mt Sinai, Dept CT Surg, New York, NY USA

[5] Johns Hopkins Med, Dept Anesthesiol & Crit Care, Baltimore, MD USA

[6] Beth Israel Deaconess Med Ctr, Dept Anesthesia, Boston, MA 02215 USA

[7] UH Cleveland Med Ctr, Dept Anesthesiol, Cleveland, OH USA

来源：

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | 2019年 / 33卷 / 02期

关键词：

heparin; anticoagulation; heparin-induced thrombocytopenia; thrombosis; cardiac surgery; critical care; ICU; CARDIOPULMONARY BYPASS; ALTERNATIVE ANTICOAGULATION; SEROTONIN-RELEASE; VALVE-REPLACEMENT; BIVALIRUDIN; ANTIBODIES; MANAGEMENT; PATIENT; ARGATROBAN; DIAGNOSIS;

D O I：

10.1053/j.jvca.2018.10.035

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Patients undergoing cardiovascular surgery may be exposed to heparin before surgery, during cardiopulmonary bypass (CPB), or in the immediate postoperative period. For this reason, cardiovascular surgery patients are at increased risk for heparin-induced thrombocytopenia (HIT), occurring in 1 to 3% of patients. The diagnosis of HIT can be difficult, if based solely on the development of thrombocytopenia, because cardiac surgical patients have multiple reasons to be thrombocytopenic. Several clinical scoring systems have been developed to reduce unnecessary testing and better define the pretest probability of HIT, which we will review in detail with a diagnostic algorithm. In addition, we will cover the prevention and treatment HIT. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：511 / 520

页数：10

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