Thermal intramolecular [2+2] cycloaddition of allenenes and allenynes: Diastereoselective access to bicyclic nitrogen heterocycles

被引：78

作者：

Ohno, H ^{[1
]}

Mizutani, T

Kadoh, Y

Miyamura, K

Tanaka, T

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 32期

关键词：

allenes; bicyclic compounds; cycloaddition; nitrogen heterocycles; regioselectivity;

D O I：

10.1002/anie.200501413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Squaring the circle: A route to bicyclo-[4.2.0]octane derivatives has been developed by the [2+2] cycloaddition of allenenes or allenynes. The thermal intramolecular [2+2] cycloaddition of simple allenes 1 with an additional multiple bond leads to direct and regioselective formation of the distal adducts 2 in good to excellent yields. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5113 / 5115

页数：3

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