The Amyloid-Congo Red Interface at Atomic Resolution

被引：120
|
作者：
Schuetz, Anne K. [2 ]
Soragni, Alice [2 ]
Hornemann, Simone [3 ]
Aguzzi, Adriano [3 ]
Ernst, Matthias [2 ]
Boeckmann, Anja [1 ]
Meier, Beat H. [2 ]
机构：
[1] Univ Lyon 1, CNRS, Inst Biol & Chim Prot, UMR 5086, F-69367 Lyon, France
[2] Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland
[3] Univ Spital Zurich, Inst Neuropathol, CH-8091 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 26期
基金：
瑞士国家科学基金会;
关键词：
amyloids; Congo red; prions; proteins; structure elucidation; ANGLE-SPINNING NMR; PROTEIN AGGREGATION; FIBRILS; BINDING; IDENTIFICATION; MECHANISM;
D O I：
10.1002/anie.201008276
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The analytical "gold standard" for amyloid characterization and diagnostics, Congo red, was studied in complex with an amyloid (see picture). Based on details of the binding mode, a point mutation of the amyloid was prepared which has the same three-dimensional structure as the wild-type protein but is not congophilic. This surprising specificity may aid in the design of selective anti-amyloidogenic drugs. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5956 / 5960
页数：5
相关论文
共 50 条
  • [1] CHEMICAL ASPECTS OF AMYLOID-CONGO RED BINDING
    ASHKENAZI, Y
    HERSKO, C
    GAFNI, J
    SOHAR, E
    HELLER, H
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1967, 3 (04): : 572 - +
  • [2] ON THE AMYLOID-CONGO RED COMPLEX IN HISTOLOGICAL SECTIONS AND THE GENESIS OF THE AMYLOID SUBSTANCE
    JOHANSSON, GA
    PFEIFFER, HH
    ACTA ANATOMICA, 1954, 20 (03): : 285 - 290
  • [3] DETERMINATION OF POLARIZATION OPTICAL-PROPERTIES OF AMYLOID-CONGO RED COMPLEX BY PHASE MODULATION MICROSPECTROPHOTOMETRY
    TAYLOR, DL
    ALLEN, RD
    BENDITT, EP
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1974, 22 (12) : 1105 - 1112
  • [4] ON BINDING OF CONGO RED BY AMYLOID
    PUCHTLER, H
    SWEAT, F
    LEVINE, M
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1962, 10 (03) : 355 - &
  • [5] Retention of Congo red in amyloid disease
    Hardgrove, MAF
    ARCHIVES OF PATHOLOGY, 1933, 15 (02): : 238 - 243
  • [6] IMPROVED CONGO RED METHOD FOR AMYLOID
    STOKES, G
    MEDICAL LABORATORY SCIENCES, 1976, 33 (01): : 79 - 80
  • [7] STUDIES ON STAINING OF AMYLOID WITH CONGO RED
    HEWLETT, BR
    CANADIAN JOURNAL OF MEDICAL TECHNOLOGY, 1966, 28 (06): : 248 - +
  • [8] On the Binding of Congo Red to Amyloid Fibrils
    Espargaro, Alba
    Llabres, Salome
    Saupe, Sven J.
    Curutchet, Caries
    Luque, F. Javier
    Sabate, Raimon
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (21) : 8104 - 8107
  • [9] Diagnosis of amyloid beyond Congo red
    Picken, Maria M.
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2021, 30 (03): : 303 - 309
  • [10] Higher detectability of amyloid with phenol Congo red compared with alkaline Congo red
    Legatowicz-Koprowska, Marta
    Szczygiel, Justyna
    Manczak, Malgorzata
    Walczak, Ewa
    REUMATOLOGIA, 2024, 62 (05): : 338 - 345
12345