Epigenetic modifications as regulatory elements of autophagy in cancer

被引：49

作者：

Sui, Xinbing ^{[1
,2
]}

Zhu, Jing ^{[3
]}

Zhou, Jichun ^{[4
]}

Wang, Xian ^{[1
,2
]}

Li, Da ^{[1
,2
]}

Han, Weidong ^{[1
,2
]}

Fang, Yong ^{[1
,2
]}

Pan, Hongming ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Hangzhou 310003, Zhejiang, Peoples R China

[2] Biomed Res Ctr, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Colorectal Surg, Hangzhou 310003, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Surg Oncol, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2015年 / 360卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Methylation; Histone; Tumor suppressor genes; Autophagy; Cancer; METHYLATION-MEDIATED REPRESSION; HISTONE DEACETYLASE INHIBITORS; CELL-DEATH; TUMOR-SUPPRESSOR; DNA METHYLATION; MESENCHYMAL TRANSITION; MOLECULAR-MECHANISM; SIGNALING PATHWAY; MTOR INHIBITION; CYTOSOLIC FOXO1;

D O I：

10.1016/j.canlet.2015.02.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic modifications have been considered as hallmarks of cancer and play an important role in tumor initiation and development. Epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs, may regulate cell cycle and apoptosis, as well as macroautophagy (hereafter referred to as autophagy). Autophagy, as a crucial cellular homeostatic mechanism, performs a dual role, having pro-survival or pro-death properties. A variety of signaling pathways including epigenetic control have been implicated in the upregulation or downregulation of autophagy. However, the role of epigenetic regulation in autophagy is still less well acknowledged. Recent studies have linked epigenetic control to the autophagic process. Some epigenetic modifiers are also involved in the regulation of autophagy and potentiate the efficacy of traditional therapeutics. Thus, understanding the novel functions of epigenetic control in autophagy may allow us to develop potential therapeutic approaches for cancer treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：106 / 113

页数：8

共 112 条

[31] SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors [J].