'Real-life' report on the management of chronic GvHD in the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

被引：6

作者：

Giaccone, L. ^{[1
,2
]}

Mancini, G. ^{[3
]}

Mordini, N. ^{[4
]}

Gargiulo, G. ^{[5
,6
]}

De Cecco, V. ^{[7
]}

Angelini, S. ^{[8
]}

Arpinati, M. ^{[9
]}

Baronciani, D. ^{[10
]}

Bozzoli, V. ^{[11
]}

Bramanti, S. ^{[12
]}

Calore, E. ^{[13
]}

Cavattoni, I. M. ^{[14
]}

Cimminiello, M. ^{[15
]}

Colombo, A. A. ^{[16
]}

Facchini, L. ^{[17
]}

Falcioni, S. ^{[18
]}

Faraci, M. ^{[19
]}

Fedele, R. ^{[20
]}

Guidi, S. ^{[21
]}

Iori, A. P. ^{[22
]}

Marotta, S. ^{[5
,6
]}

Mico, M. C. ^{[23
]}

Milone, G. ^{[24
]}

Onida, F. ^{[25
]}

Pastore, D. ^{[26
]}

Patriarca, F. ^{[27
]}

Pini, M. ^{[28
]}

Raimondi, R. ^{[29
]}

Rovelli, A. ^{[30
]}

Santarone, S. ^{[31
]}

Severino, A. ^{[32
]}

Skert, C. ^{[33
]}

Stanghellini, M. T. L. ^{[34
]}

Tecchio, C. ^{[35
]}

Vassallo, E. ^{[36
]}

Chiarucci, M. ^{[3
]}

Bruno, B. ^{[1
,2
]}

Bonifazi, F. ^{[9
]}

Olivieri, A. ^{[3
]}

机构：

[1] Univ Torino, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

[2] Univ Torino, Dept Oncol, AOU Citta Salute & Sci Torino, Turin, Italy

[3] Azienda Osped Univ Ospedali Riuniti, Div Hematol, Ancona, Italy

[4] Azienda Osped S Croce & Carle, Div Hematol, Cuneo, Italy

[5] UOC Ematol, Naples, Italy

[6] AOU Federico II, TCSE, Naples, Italy

[7] Fdn IRCCS Policlin San Matteo, UOC Oncoematol Pediat, Pavia, Italy

[8] Osped Mazzoni, Div Hematol & Stem Cell Transplantat, Ascoli Piceno, Italy

[9] Univ Hosp SantOrsola Malpighi, Div Hematol, Bologna, Italy

[10] Osped Riferimento Reg Businco, AO Brotzu, Cagliari, Italy

[11] Osped Lecce, Div Ematol, Lecce, Italy

[12] Osped Humanitas, Div Hematol, Rozzano, Italy

[13] Univ Hosp Padova, Clin Pediat Hematooncol, Dept Womens & Childrens Hlth, Padua, Italy

[14] Osped Cent Bolzano, Hematol & Bone Marrow Transplant Unit, Bolzano, Italy

[15] UOC Ematologia TMO, Osped San Carlo, Potenza, Italy

[16] Fdn IRCCS Policlin San Matteo, Div Ematol, Pavia, Italy

[17] Arcispedale S Maria Nuova IRCCS, Hematol Unit, Reggio Emilia, Italy

[18] UOC Ematol Trapianto Cellule Staminali Emopoiet, Osped Mazzoni, Ascoli Piceno, Italy

[19] IRCCS G Gaslini, Dept Pediat Hematol Oncol, Genoa, Italy

[20] Azienda Osped Bianchi Melacrino Morelli, Hematol & Stem Cell Transplant Unit, Reggio Di Calabria, Italy

[21] Univ Firenze, Bone Marrow Transplant Unit, Dept Hematol, Florence, Italy

[22] Univ Roma La Sapienza, Azienda Policlin Umberto, Dept Cellular Biotechnol & Hematol, Rome, Italy

[23] Azienda Osped Papa Giovanni XXIII, Hematol & Bone Marrow Transplant Unit, Bergamo, Italy

[24] Azienda Policlin Vittorio Emanuele, Hematol & Bone Marrow Transplant Unit, Catania, Italy

[25] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Hematol BMT Ctr, Milan, Italy

[26] Univ Bari, Dipartimento Ematol, Bari, Italy

[27] Univ Udine, DISM, Azienda Osped, Udine, Italy

[28] AO SS Antonio & Biagio & C Arrigo, Hematol, Alessandria, Italy

[29] Osped San Bortolo, Hematol & Bone Marrow Transplant Unit, Vicenza, Italy

[30] Univ Milano Bicocca, San Gerardo Hosp, Paediat Dept, MBBM Fdn,BMT Unit, Monza, Italy

[31] Osped Civile, Unita Terapia Intens Ematol Trapianto Emopoiet, Pescara, Italy

[32] Osped San Camillo, Div Ematol, Rome, Italy

[33] Univ Brescia, Dept Clin & Expt Sci, Unit Blood Dis & Stem Transplantat, AO Spedali Civili Brescia, Brescia, Italy

[34] IRCCS San Raffaele Sci Inst, Mol Hematol Lab, Milan, Italy

[35] Univ Verona, Sect Hematol, Dept Med, Verona, Italy

[36] AO Citta Salute & Sci Torino, Pediat Oncohematol & Stem Cell Transplant Div, Turin, Italy

来源：

BONE MARROW TRANSPLANTATION | 2018年 / 53卷 / 01期

关键词：

VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; WORKING GROUP-REPORT; HEMATOPOIETIC-CELL TRANSPLANTATION; CHRONIC GRAFT; CLINICAL-TRIALS; MARROW-TRANSPLANTATION; RANDOMIZED-TRIAL; SUPPORTIVE CARE; BONE-MARROW;

D O I：

10.1038/bmt.2017.223

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Several guidelines have been published about management of chronic GvHD (cGvHD), but the clinical practice still remains demanding. The Gruppo Italiano Trapianto di Midollo Osseo (GITMO) has planned a prospective observational study on cGvHD, supported by a dedicated software, including the updated recommendations. In view of this study, two surveys have been conducted, focusing the management of cGvHD and ancillary therapy in cGvHD, to address the current 'real life' situation. The two surveys were sent to all 57 GITMO centers, performing allografting in Italy; the response rate was 57% and 66% of the interviewed centers, respectively. The first survey showed a great disparity especially regarding steroid-refractory cGvHD, although extracorporeal photo-apheresis resulted as the most indicated treatment in this setting. Another challenging issue was the strategy for tapering steroid: our survey showed a great variance, and this disagreement could be a real bias in evaluating outcomes in prospective studies. As for the second survey, the results suggest that the ancillary treatments are not standardized in many centers. All responding centers reported a strong need to standardize management of cGvHD and to participate in prospective trials. Before starting observational and/or interventional studies, a detailed knowledge of current practice should be encouraged.

引用

页码：58 / 63

页数：6

共 9 条

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