Identification and Characterization of Human Endometrial Mesenchymal Stem/Stromal Cells and Their Potential for Cellular Therapy

被引：86
作者：
Darzi, Saeedeh [1 ,2 ]
Werkmeister, Jerome A. [2 ,3 ]
Deane, James A. [1 ,2 ]
Gargett, Caroline E. [1 ,2 ]
机构：
[1] Hudson Inst Med Res, Ritchie Ctr, 27-31 Wright St, Clayton, Vic 3168, Australia
[2] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic, Australia
[3] CSIRO, Clayton, Vic, Australia
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2016年 / 5卷 / 09期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
STEM-CELLS; STROMAL CELLS; BONE-MARROW; MENSTRUAL BLOOD; STEM/PROGENITOR CELLS; INTERNATIONAL-SOCIETY; TEMPORAL-CHANGES; SCIENCE; CULTURE; ANTIBODIES;
D O I：
10.5966/sctm.2015-0190
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human endometrium is a highly regenerative tissue, undergoing more than 400 cycles of proliferation, differentiation, and shedding during a woman's reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.
引用
收藏
页码：1127 / 1132
页数：6
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