Identification and Characterization of Human Endometrial Mesenchymal Stem/Stromal Cells and Their Potential for Cellular Therapy

被引：86
作者：
Darzi, Saeedeh [1 ,2 ]
Werkmeister, Jerome A. [2 ,3 ]
Deane, James A. [1 ,2 ]
Gargett, Caroline E. [1 ,2 ]
机构：
[1] Hudson Inst Med Res, Ritchie Ctr, 27-31 Wright St, Clayton, Vic 3168, Australia
[2] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic, Australia
[3] CSIRO, Clayton, Vic, Australia
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2016年 / 5卷 / 09期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
STEM-CELLS; STROMAL CELLS; BONE-MARROW; MENSTRUAL BLOOD; STEM/PROGENITOR CELLS; INTERNATIONAL-SOCIETY; TEMPORAL-CHANGES; SCIENCE; CULTURE; ANTIBODIES;
D O I：
10.5966/sctm.2015-0190
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human endometrium is a highly regenerative tissue, undergoing more than 400 cycles of proliferation, differentiation, and shedding during a woman's reproductive life. Adult stem cells, including mesenchymal stem/stromal cells (MSCs), are likely responsible for the immense cellular turnover in human endometrium. The unique properties of MSCs, including high proliferative ability, self-renewal, differentiation to mesodermal lineages, secretion of angiogenic factors, and many other growth-promoting factors make them useful candidates for cellular therapy and tissue engineering. In this review, we summarize the identification and characterization of newly discovered MSCs from the human endometrium: their properties, the surface markers used for their prospective isolation, their perivascular location in the endometrium, and their potential application in cellular therapies.
引用
收藏
页码：1127 / 1132
页数：6
相关论文
共 50 条
[1]   Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1 [J].
Battula, Venkata Lokesh ;
Treml, Sabrina ;
Bareiss, Petra M. ;
Gieseke, Friederike ;
Roelofs, Helene ;
de Zwart, Peter ;
Mueller, Ingo ;
Schewe, Bernhard ;
Skutella, Thomas ;
Fibbe, Willem E. ;
Kanz, Lothar ;
Buehring, Hans-Joerg .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (02) :173-184
[2]   Impact of Aging on the Regenerative Properties of Bone Marrow-, Muscle-, and Adipose-Derived Mesenchymal Stem/Stromal Cells [J].
Beane, Olivia S. ;
Fonseca, Vera C. ;
Cooper, Leroy L. ;
Koren, Gideon ;
Darling, Eric M. .
PLOS ONE, 2014, 9 (12)
[3]   Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine? [J].
Bernardo, M. E. ;
Pagliara, D. ;
Locatelli, F. .
BONE MARROW TRANSPLANTATION, 2012, 47 (02) :164-171
[4]   The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine [J].
Bianco, Paolo ;
Cao, Xu ;
Frenette, Paul S. ;
Mao, Jeremy J. ;
Robey, Pamela G. ;
Simmons, Paul J. ;
Wang, Cun-Yu .
NATURE MEDICINE, 2013, 19 (01) :35-42
[5]   Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT) [J].
Bourin, Philippe ;
Bunnell, Bruce A. ;
Casteilla, Louis ;
Dominici, Massimo ;
Katz, Adam J. ;
March, Keith L. ;
Redl, Heinz ;
Rubin, J. Peter ;
Yoshimura, Kotaro ;
Gimble, Jeffrey M. .
CYTOTHERAPY, 2013, 15 (06) :641-648
[6]   Isolation and Characterization of Human Mesenchymal Stromal Cell Subpopulations: Comparison of Bone Marrow and Adipose Tissue [J].
Busser, Helene ;
Najar, Mehdi ;
Raicevic, Gordana ;
Pieters, Karlien ;
Pombo, Rafael Velez ;
Philippart, Pierre ;
Meuleman, Nathalie ;
Bron, Dominique ;
Lagneaux, Laurence .
STEM CELLS AND DEVELOPMENT, 2015, 24 (18) :2142-2157
[7]   Identification of label-retaining cells in mouse endometrium [J].
Chan, Rachel W. S. ;
Gargett, Caroline E. .
STEM CELLS, 2006, 24 (06) :1529-1538
[8]   Clonogenicity of human endometrial epithelial and stromal cellss [J].
Chan, RWS ;
Schwab, KE ;
Gargett, CE .
BIOLOGY OF REPRODUCTION, 2004, 70 (06) :1738-1750
[9]   A perivascular origin for mesenchymal stem cells in multiple human organs [J].
Crisan, Mihaela ;
Yap, Solomon ;
Casteilla, Louis ;
Chen, Chien-Wen ;
Corselli, Mirko ;
Park, Tea Soon ;
Andriolo, Gabriella ;
Sun, Bin ;
Zheng, Bo ;
Zhang, Li ;
Norotte, Cyrille ;
Teng, Pang-Ning ;
Traas, Jeremy ;
Schugar, Rebecca ;
Deasy, Bridget M. ;
Badylak, Stephen ;
Buehring, Hans-Joerg ;
Giacobino, Jean-Paul ;
Lazzari, Lorenza ;
Huard, Johnny ;
Peault, Bruno .
CELL STEM CELL, 2008, 3 (03) :301-313
[10]   Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies [J].
D'souza, Naomi ;
Rossignoli, Filippo ;
Golinelli, Giulia ;
Grisendi, Giulia ;
Spano, Carlotta ;
Candini, Olivia ;
Osturu, Satoru ;
Catani, Fabio ;
Paolucci, Paolo ;
Horwitz, Edwin M. ;
Dominici, Massimo .
BMC MEDICINE, 2015, 13
12345