Lipid goal attainment in post-acute coronary syndrome patients in China: Results from the 6-month real-world dyslipidemia international study II

被引：25

作者：

Gong, Yanjun ^{[1
]}

Li, Xuan ^{[2
]}

Ma, Xiang ^{[3
]}

Yu, Hongwei ^{[4
]}

Li, Ying ^{[5
]}

Chen, Jiyan ^{[6
]}

Zhang, Guochun ^{[7
]}

Wang, Bin ^{[8
]}

Qi, Xiaoyong ^{[9
]}

Meng, Haiyan ^{[10
]}

Wang, Xiaofeng ^{[11
]}

Mu, Jianjun ^{[12
]}

Hu, Xitian ^{[13
]}

Wang, Jingping ^{[14
]}

Liu, Shaowen ^{[15
]}

Liu, Gang ^{[16
]}

Yang, Zhenyu ^{[17
]}

Zhou, Yujie ^{[18
]}

Kong, Xiangqing ^{[19
]}

Yan, Yuhu ^{[20
]}

Wang, Changqian ^{[21
]}

Wang, Jian' An ^{[22
]}

Wang, Lijun ^{[23
]}

Fu, Guosheng ^{[24
]}

Wei, Lin ^{[25
]}

Peng, Daoquan ^{[26
]}

Zhang, Shuyang ^{[27
]}

Li, Ruogu ^{[28
]}

Mao, Anhua ^{[29
]}

Bian, Rui ^{[29
]}

Tang, Wenmin ^{[29
]}

Ran, Yuqin ^{[29
]}

Jiang, Jie ^{[1
]}

Huo, Yong ^{[1
]}

机构：

[1] Peking Univ First Hosp, Dept Cardiol, Beijing 100034, Peoples R China

[2] Jinqiu Hosp Liaoning Prov, Dept Cardiol, Shenyang, Peoples R China

[3] Xinjiang Med Univ, Affiliated Hosp 1, Dept Cardiol, Urumqi, Peoples R China

[4] Zhengzhou First Peoples Hosp, Dept Cardiol, Zhengzhou, Peoples R China

[5] Shanghai East Hosp, Dept Cardiol, Shanghai, Peoples R China

[6] Guangdong Prov Peoples Hosp, Dept Cardiol, Guangzhou, Peoples R China

[7] Second Hosp Harbin, Dept Cardiol, Harbin, Peoples R China

[8] Shantou Univ, Affiliated Hosp 1, Med Coll, Dept Cardiol, Shantou, Peoples R China

[9] Hebei Gen Hosp, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China

[10] Shandong Prov Third Hosp, Dept Rehabil, Jinan, Peoples R China

[11] Tradit Chinese Med Hosp Xinjiang Uygur Autonomous, Dept Cardiol, Urumqi, Peoples R China

[12] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiol, Xian, Peoples R China

[13] Shijiazhuang First Hosp, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China

[14] Cardiovasc Hosp Shanxi Prov, Dept Cardiol, Taiyuan, Peoples R China

[15] Shanghai Gen Hosp, Dept Cardiol, Shanghai, Peoples R China

[16] Hebei Med Univ, Hosp 1, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China

[17] Wuxi Peoples Hosp, Dept Cardiol, Wuxi, Jiangsu, Peoples R China

[18] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China

[19] Jiangsu Prov Hosp, Dept Cardiol, Nanjing, Peoples R China

[20] Jinzhong First Peoples Hosp, Dept Cardiol, Jinzhong, Peoples R China

[21] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Cardiol, Shanghai, Peoples R China

[22] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol, Hangzhou, Peoples R China

[23] Shijiazhuang Third Hosp, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China

[24] Zhejiang Univ, Sch Med, Sir Run Shaw Hosp, Dept Cardiol, Hangzhou, Peoples R China

[25] First Hosp Harbin, Dept Cardiol, Harbin, Peoples R China

[26] Cent South Univ, Xiangya Hosp 2, Dept Cardiol, Changsha, Peoples R China

[27] Peking Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China

[28] Shanghai Chest Hosp, Dept Cardiol, Shanghai, Peoples R China

[29] MSD China, Global Med & Sci Affairs GMSA, Shanghai, Peoples R China

来源：

CLINICAL CARDIOLOGY | 2021年 / 44卷 / 11期

关键词：

acute coronary syndrome; DYSIS II; LDL-C goal; lipid-lowering therapy; statin; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR OUTCOMES; LDL CHOLESTEROL; GLOBAL REGISTRY; STATIN THERAPY; GUIDELINES; MANAGEMENT; DISEASE; HYPERCHOLESTEROLEMIA; METAANALYSIS;

D O I：

10.1002/clc.23725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Dyslipidemia International Study II (DYSIS II)-China was conducted to determine the low-density lipoprotein cholesterol (LDL-C) goal (<1.8 mmol/L) attainment rate in patients with post-acute coronary syndrome (ACS). Hypothesis Compliance with treatment guideline recommendations improves the LDL-C goal attainment rate in post-ACS patients. Methods This multicenter prospective observational study conducted at 28 tertiary hospitals determined the LDL-C goal attainment rates at admission and 6-month follow-up in patients on lipid-lowering treatment (LLT) for >= 3 months and those not on LLT (LLT-naive or off LLT for >= 3 months) at admission. Predictors of goal attainment at 6 months were identified using multivariate logistic regression. Results The LDL-C goal attainment rate at admission in 1102/1103 enrolled patients was 17.1%; it was 41.2% among 752 patients with available lipid results at 6 months. The distance to goal was 0.7 mmol/L at 6 months. Statin monotherapy was the most prescribed LLT. Only 7.7% of patients were receiving statin + ezetimibe and 8.4% of patients were receiving an atorvastatin-equivalent dose of >= 40 mg/day at 6 months. Being male (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.1-2.6) and undergoing percutaneous coronary intervention during index hospitalization (OR 1.5, 95% CI 1.1 to 2.1) were the independent predictors for LDL-C goal attainment. Conclusions This real-world DYSIS II study in China reports a low LDL-C goal attainment rate in post-ACS patients even after 6 months of LLT. Lack of intensification of statin therapy and underutilization of combinations suggest gaps between real-world treatment practices and guideline recommendations.

引用

页码：1575 / 1585

页数：11