Novel amphiphilic diblock copolymers bearing acid-labile oxazolidine moieties: Synthesis, self-assembly and responsive behavior in aqueous solution

被引：20

作者：

Cui, Qianling ^{[1
,2
]}

Wu, Feipeng ^{[1
]}

Wang, Erjian ^{[1
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

POLYMER | 2011年 / 52卷 / 08期

关键词：

Amphiphilic diblock copolymers; pH-responsivity; RAFT polymerization; TRANSFER RADICAL POLYMERIZATION; WATER-SOLUBLE POLYMERS; DRUG-DELIVERY SYSTEMS; CROSS-LINKED MICELLES; BLOCK-COPOLYMERS; POLY(ORTHO ESTERS); HYDROLYSIS; RELEASE; GLYCOL); MICELLIZATION;

D O I：

10.1016/j.polymer.2011.02.022

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel oxazolidine based acid-labile monomer N-acryloyl-2,2-dimethyl-1,3-oxazolidine (ADMO) was synthesized and polymerized by reversible addition fragmentation chain transfer (RAFT) polymerization using poly(ethylene glycol) based chain transfer agent (PEG-CTA). The diblock copolymers PEG-b-PADMO were composed of hydrophilic PEG with fixed length and hydrophobic PADMO with different lengths, which formed core-shell micelles in water. Morphologies and sizes of micelles were obtained by transmission electron microscopy (TEM) and dynamic light scattering (DLS), which showed that the shapes of polymeric aggregates developed from small spherical micelles, worm-like micelles to larger size of vesicles, as the length of PADMO increased. The hydrolysis kinetics of the micelles was studied using H-1 NMR, DLS and release of loaded Nile Red dye, whose rate strongly depended on pH and micellar structure. It led to the disruption of polymeric micelles and concomitant release of the guest molecules, due to the transformation of hydrophobic PADMO into hydrophilic poly(2-hydroxyethyl acrylamide) (PHEAM). (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1755 / 1765

页数：11

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